Literature DB >> 2760963

The effect of high cholesterol, high fat diet on rabbit plasma beta-VLDL and its interaction with macrophage.

S P Wang, Z C Feng, Y M Feng, W S Wu, C B Wang, W G Jiang, W X Dai, J G Liang.   

Abstract

Rabbits were fed on 1% cholesterol and 10% rape seed oil (group A) or lard (group B). Plasma cholesterol and triglyceride level of group A was strikingly lower than that of group B. No difference was found in the lipid composition of beta-VLDLs between both groups. However, apo E content of beta-VLDL from group A was higher and apo B (higher molecular weight) was lower than that of group B respectively. beta-VLDL of group A caused greater accumulation of cholesterol in mouse peritoneal macrophage than that of group B. Therefore, we assume that the good effect of poly-unsaturated fatty acid on atherosclerosis results not from decreasing accumulation of cholesterol in macrophages but from enhancing elimination of beta-VLDL by the liver.

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Year:  1989        PMID： 2760963     DOI： 10.1007/BF02933743

Source DB:  PubMed          Journal:  J Tongji Med Univ        ISSN： 0257-716X


  11 in total

Review 1.  Low density lipoproteins in atherosclerosis.

Authors:  L L Rudel; J S Parks; F L Johnson; J Babiak
Journal:  J Lipid Res       Date:  1986-05       Impact factor: 5.922

Review 2.  Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis.

Authors:  M S Brown; J L Goldstein
Journal:  Annu Rev Biochem       Date:  1983       Impact factor: 23.643

3.  Atherogenic lipoproteins and coronary artery disease: concepts derived from recent advances in cellular and molecular biology.

Authors:  R W Mahley
Journal:  Circulation       Date:  1985-11       Impact factor: 29.690

4.  Dietary saturated triacylglycerols suppress hepatic low density lipoprotein receptor activity in the hamster.

Authors:  D K Spady; J M Dietschy
Journal:  Proc Natl Acad Sci U S A       Date:  1985-07       Impact factor: 11.205

5.  Apo E-mediated uptake and degradation of normal very low density lipoproteins by human monocyte/macrophages: a saturable pathway distinct from the LDL receptor.

Authors:  P Wang-Iverson; H N Ginsberg; L A Peteanu; N A Le; W V Brown
Journal:  Biochem Biophys Res Commun       Date:  1985-01-16       Impact factor: 3.575

6.  Aortic accumulation and plasma clearance of beta-VLDL and HDL: effects of diet-induced hypercholesterolemia in rabbits.

Authors:  A Daugherty; L G Lange; B E Sobel; G Schonfeld
Journal:  J Lipid Res       Date:  1985-08       Impact factor: 5.922

7.  Metabolism of apolipoproteins B-48 and B-100 of triglyceride-rich lipoproteins in normal and lipoprotein lipase-deficient humans.

Authors:  A F Stalenhoef; M J Malloy; J P Kane; R J Havel
Journal:  Proc Natl Acad Sci U S A       Date:  1984-03       Impact factor: 11.205

8.  Cholesteryl ester accumulation in macrophages resulting from receptor-mediated uptake and degradation of hypercholesterolemic canine beta-very low density lipoproteins.

Authors:  J L Goldstein; Y K Ho; M S Brown; T L Innerarity; R W Mahley
Journal:  J Biol Chem       Date:  1980-03-10       Impact factor: 5.157

9.  Metabolism of two forms of apolipoprotein B of VLDL by rat liver.

Authors:  C E Sparks; D J Rader; J B Marsh
Journal:  J Lipid Res       Date:  1983-02       Impact factor: 5.922

10.  Cholesteryl ester synthesis in macrophages: stimulation by beta-very low density lipoproteins from cholesterol-fed animals of several species.

Authors:  R W Mahley; T L Innerarity; M S Brown; Y K Ho; J L Goldstein
Journal:  J Lipid Res       Date:  1980-11       Impact factor: 5.922
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