| Literature DB >> 27609282 |
Jorge Barrios-Payán1, Alberto Revuelta2, Dulce Mata-Espinosa3, Brenda Marquina-Castillo4, Enrique Becerril Villanueva5, María Eugenia Hernández Gutiérrez6, Gilberto Pérez-Sánchez7, Lenin Pavón8, Rogelio Hernandez-Pando9.
Abstract
The role of norepinephrine (NE) in the immunopathology of experimental tuberculosis (TB) was studied by measuring pulmonary NE and determining its cellular sources and targets. Functional studies were performed administrating adrenergic and anti-adrenergic drugs at different TB phases. Results showed high production of NE during early infection by adrenergic nerve terminals and lymphocytes located in the lungs and mediastinal lymph nodes, these cells highly expressed β2 adreno-receptors (β2AR) which by an autocrine mechanism promote Th-1 cell differentiation favoring protection. During advanced infection, the production of NE and β2AR sharply decreased, suggesting that adrenergic activity is less important during late TB.Entities:
Keywords: Norepinephrine; Sympathetic system; Tuberculosis; Tyrosine-hydroxylase; β-2 adrenoreceptor
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Year: 2016 PMID： 27609282 DOI： 10.1016/j.jneuroim.2016.07.012
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478