Literature DB >> 27608776

Nickel-Catalyzed Site-Selective C-H Bond Difluoroalkylation of 8-Aminoquinolines on the C5-Position.

Hao Chen1, Pinhua Li1, Min Wang1, Lei Wang1,2.   

Abstract

A simple and efficient protocol for nickel-catalyzed regioselective C-H bond difluoroalkylation of 8-aminoquinoline scaffolds with functionalized difluoromethyl bromides was developed. The reaction has broad substrate scope and provides a facile and useful access to the corresponding C5-functionalized difluoromethylated quinolines in good to excellent yields.

Entities:  

Year:  2016        PMID： 27608776     DOI： 10.1021/acs.orglett.6b02166

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

Review 1.  A comprehensive overview of directing groups applied in metal-catalysed C-H functionalisation chemistry.

Authors:  Carlo Sambiagio; David Schönbauer; Remi Blieck; Toan Dao-Huy; Gerit Pototschnig; Patricia Schaaf; Thomas Wiesinger; Muhammad Farooq Zia; Joanna Wencel-Delord; Tatiana Besset; Bert U W Maes; Michael Schnürch
Journal:  Chem Soc Rev       Date:  2018-08-28       Impact factor: 54.564

2.  An efficient nickel/silver co-catalyzed remote C-H amination of 8-aminoquinolines with azodicarboxylates at room temperature.

Authors:  Ruinan Zhao; Yaocheng Yang; Xia Wang; Peng Ren; Qian Zhang; Dong Li
Journal:  RSC Adv       Date:  2018-11-05       Impact factor: 4.036

3.  Direct heterobenzylic fluorination, difluorination and trifluoromethylthiolation with dibenzenesulfonamide derivatives.

Authors:  Michael Meanwell; Bharani Shashank Adluri; Zheliang Yuan; Josiah Newton; Philippe Prevost; Matthew B Nodwell; Chadron M Friesen; Paul Schaffer; Rainer E Martin; Robert Britton
Journal:  Chem Sci       Date:  2018-06-07       Impact factor: 9.825

4.  Nitrogen-doped graphene-activated metallic nanoparticle-incorporated ordered mesoporous carbon nanocomposites for the hydrogenation of nitroarenes.

Authors:  Haigen Huang; Xueguang Wang; Yao Sheng; Chenju Chen; Xiujing Zou; Xingfu Shang; Xionggang Lu
Journal:  RSC Adv       Date:  2018-02-26       Impact factor: 3.361
  4 in total

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