OBJECTIVE: Photoacoustic (PA) imaging emerges as a unique tool to study biological samples based on optical absorption contrast. In PA imaging, piezoelectric transducers are commonly used to detect laser-induced ultrasonic waves. However, they typically lack adequate broadband sensitivity at ultrasonic frequency higher than 100 MHz, whereas their bulky size and optically opaque nature cause technical difficulties in integrating PA imaging with conventional optical imaging modalities. To overcome these limitations, optical methods of ultrasound detection were developed and shown their unique applications in PA imaging. METHODS: We provide an overview of recent technological advances in optical methods of ultrasound detection and their applications in PA imaging. A general theoretical framework describing sensitivity, bandwidth, and angular responses of optical ultrasound detection is also introduced. RESULTS: Optical methods of ultrasound detection can provide improved detection angle and sensitivity over significantly extended bandwidth. In addition, its versatile variants also offer additional advantages, such as device miniaturization, optical transparency, mechanical flexibility, minimal electrical/mechanical crosstalk, and potential noncontact PA imaging. CONCLUSION: The optical ultrasound detection methods discussed in this review and their future evolution may play an important role in PA imaging for biomedical study and clinical diagnosis.
OBJECTIVE: Photoacoustic (PA) imaging emerges as a unique tool to study biological samples based on optical absorption contrast. In PA imaging, piezoelectric transducers are commonly used to detect laser-induced ultrasonic waves. However, they typically lack adequate broadband sensitivity at ultrasonic frequency higher than 100 MHz, whereas their bulky size and optically opaque nature cause technical difficulties in integrating PA imaging with conventional optical imaging modalities. To overcome these limitations, optical methods of ultrasound detection were developed and shown their unique applications in PA imaging. METHODS: We provide an overview of recent technological advances in optical methods of ultrasound detection and their applications in PA imaging. A general theoretical framework describing sensitivity, bandwidth, and angular responses of optical ultrasound detection is also introduced. RESULTS: Optical methods of ultrasound detection can provide improved detection angle and sensitivity over significantly extended bandwidth. In addition, its versatile variants also offer additional advantages, such as device miniaturization, optical transparency, mechanical flexibility, minimal electrical/mechanical crosstalk, and potential noncontact PA imaging. CONCLUSION: The optical ultrasound detection methods discussed in this review and their future evolution may play an important role in PA imaging for biomedical study and clinical diagnosis.
Authors: Vladislav V Yakovlev; Wayne Dickson; Antony Murphy; John McPhillips; Robert J Pollard; Viktor A Podolskiy; Anatoly V Zayats Journal: Adv Mater Date: 2013-03-01 Impact factor: 30.849
Authors: Han-Wei Wang; Ning Chai; Pu Wang; Song Hu; Wei Dou; David Umulis; Lihong V Wang; Michael Sturek; Robert Lucht; Ji-Xin Cheng Journal: Phys Rev Lett Date: 2011-06-10 Impact factor: 9.161
Authors: Edward Z Zhang; Boris Povazay; Jan Laufer; Aneesh Alex; Bernd Hofer; Barbara Pedley; Carl Glittenberg; Bradley Treeby; Ben Cox; Paul Beard; Wolfgang Drexler Journal: Biomed Opt Express Date: 2011-07-08 Impact factor: 3.732
Authors: Sunish J Mathews; Callum Little; Christopher D Loder; Roby D Rakhit; Wenfeng Xia; Edward Z Zhang; Paul C Beard; Malcolm C Finlay; Adrien E Desjardins Journal: Photoacoustics Date: 2018-07-24