Giuseppe Pantaleo1, Yves Levy. 1. aService of Immunology and AllergybSwiss Vaccine Research Institute, Lausanne University Hospital, University of Lausanne, Lausanne, SwitzerlandcINSERM U955, Paris Est Créteil UniversitydGroupe Hospitalier Henri-Mondor Albert-CheneviereVaccine Research Institute, Créteil, France.
Abstract
PURPOSE OF REVIEW: The purpose is to review current knowledge of immunological interventions in HIV infection and discuss strategies for the establishment of functional cure and/or HIV eradication. RECENT FINDINGS: Therapeutic vaccines and cytokines have been historically the immunological interventions developed with the objective to enhance the HIV-specific cell-mediated immune responses and to suppress virus replication. Both these interventions have shown only partial antiviral effects. The recent identification and generation of human broad neutralizing antibodies provides potent immunological intervention associated with effective suppression of virus replication in the absence of antiretroviral therapy. Furthermore, the identification that the major HIV cell reservoir containing replication competent and infectious virus is composed by programed cell death protein 1 (PD-1) positive memory CD4 T cells offers the opportunity to target directly the HIV cell reservoir with anti-PD-1 antibodies. Anti-PD-1 antibody therapy may be also critical to prevent exhaustion of CD8 T cells. SUMMARY: The availability of a diverse armamentarium of immunological intervention offers the opportunity to investigate the efficacy of the combined use of different immunological interventions in inducing prolonged virus suppression in the absence of antiretroviral therapy and functional cure HIV or HIV eradication.
PURPOSE OF REVIEW: The purpose is to review current knowledge of immunological interventions in HIV infection and discuss strategies for the establishment of functional cure and/or HIV eradication. RECENT FINDINGS: Therapeutic vaccines and cytokines have been historically the immunological interventions developed with the objective to enhance the HIV-specific cell-mediated immune responses and to suppress virus replication. Both these interventions have shown only partial antiviral effects. The recent identification and generation of human broad neutralizing antibodies provides potent immunological intervention associated with effective suppression of virus replication in the absence of antiretroviral therapy. Furthermore, the identification that the major HIV cell reservoir containing replication competent and infectious virus is composed by programed cell death protein 1 (PD-1) positive memory CD4 T cells offers the opportunity to target directly the HIV cell reservoir with anti-PD-1 antibodies. Anti-PD-1 antibody therapy may be also critical to prevent exhaustion of CD8 T cells. SUMMARY: The availability of a diverse armamentarium of immunological intervention offers the opportunity to investigate the efficacy of the combined use of different immunological interventions in inducing prolonged virus suppression in the absence of antiretroviral therapy and functional cure HIV or HIV eradication.
Authors: Guoxin Wu; Michael Swanson; Aarthi Talla; Donald Graham; Julie Strizki; Daniel Gorman; Richard Jo Barnard; Wade Blair; Ole S Søgaard; Martin Tolstrup; Lars Østergaard; Thomas A Rasmussen; Rafick-Pierre Sekaly; Nancie M Archin; David M Margolis; Daria J Hazuda; Bonnie J Howell Journal: JCI Insight Date: 2017-08-17
Authors: Jimena Salido; María Julia Ruiz; César Trifone; María Inés Figueroa; María Paula Caruso; María Magdalena Gherardi; Omar Sued; Horacio Salomón; Natalia Laufer; Yanina Ghiglione; Gabriela Turk Journal: Front Immunol Date: 2018-10-23 Impact factor: 7.561
Authors: Gilberto Filaci; Daniela Fenoglio; Lucia Taramasso; Francesco Indiveri; Antonio Di Biagio Journal: Front Immunol Date: 2018-10-23 Impact factor: 7.561