Antonio Marcos Birocale1, Ana Raquel Santos Medeiros2, Leandro Dias Gonçalves Ruffoni3, Liliam Takayama4, José Martins de Oliveira5, Keico Okino Nonaka3, Rosa Maria Rodrigues Pereira4, Nazaré Souza Bissoli6. 1. Department of Health Integrated Education, Federal University of Espirito Santo,Vitória, Brazil. Electronic address: mbirocale@hotmail.com. 2. Biological and Health Sciences, Federal Institute of Espirito Santo, Vitória, Brazil. 3. Department of Physiological Sciences, Federal University of São Carlos, São Carlos, Brazil. 4. Department of Medical Clinic, Medicine College, University of São Paulo, São Paulo, Brazil. 5. Laboratory of Applied Nuclear Physics, University of Sorocaba, Sorocaba, Brazil. 6. Department of Physiological Sciences, Federal University of Espirito Santo, Vitória, Brazil.
Abstract
BACKGROUND: Telmisartan, an angiotensin AT1 receptor blocker, and treadmill running were compared for their effects on bone mineral density (BMD) and biomechanical properties of male spontaneously hypertensive rats (SHR). It was hypothesized that running (18m/min/60min/d) and telmisartan (5mg/kg/d) would have a positive effect on bone parameters. METHODS: Three-month-old male SHRs were divided into three groups: sedentary (S), telmisartan (T), and exercise (E). At the end of an 8-week protocol, femur and lumbar vertebrae were analyzed by dual-energy X-ray absorptiometry (DXA) for bone mineral density and by the three-point bending test for biomechanical properties. Blood pressure in all groups was measured by a tail-cuff manometer. RESULTS: Telmisartan and treadmill running reduced blood pressure when compared to the sedentary group; however, telmisartan did not improve bone characteristics. Instead, it reduced BMD of femur total and lumbar vertebrae and worsened bone biomechanic properties. Treadmill running maintained bone characteristics and hence was effective in maintaining bone health. CONCLUSION: Results showed that telmisartan negatively affected bones suggesting that caution should be taken in possible therapeutic applications for protecting bone health in hypertensive conditions. More studies are necessary to clarify the mechanisms through which telmisartan favors bone loss in this model.
BACKGROUND:Telmisartan, an angiotensin AT1 receptor blocker, and treadmill running were compared for their effects on bone mineral density (BMD) and biomechanical properties of male spontaneously hypertensiverats (SHR). It was hypothesized that running (18m/min/60min/d) and telmisartan (5mg/kg/d) would have a positive effect on bone parameters. METHODS: Three-month-old male SHRs were divided into three groups: sedentary (S), telmisartan (T), and exercise (E). At the end of an 8-week protocol, femur and lumbar vertebrae were analyzed by dual-energy X-ray absorptiometry (DXA) for bone mineral density and by the three-point bending test for biomechanical properties. Blood pressure in all groups was measured by a tail-cuff manometer. RESULTS:Telmisartan and treadmill running reduced blood pressure when compared to the sedentary group; however, telmisartan did not improve bone characteristics. Instead, it reduced BMD of femur total and lumbar vertebrae and worsened bone biomechanic properties. Treadmill running maintained bone characteristics and hence was effective in maintaining bone health. CONCLUSION: Results showed that telmisartan negatively affected bones suggesting that caution should be taken in possible therapeutic applications for protecting bone health in hypertensive conditions. More studies are necessary to clarify the mechanisms through which telmisartan favors bone loss in this model.
Authors: Jennifer L Hargrove; Yvonne M Golightly; Virginia Pate; Carri H Casteel; Laura R Loehr; Stephen W Marshall; Til Stürmer Journal: Inj Epidemiol Date: 2017-10-18
Authors: Emanuel E C Polisel; Wladimir R Beck; Pedro P M Scariot; Taciane M M Pejon; Claudio A Gobatto; Fúlvia B Manchado-Gobatto Journal: Sci Rep Date: 2021-03-19 Impact factor: 4.379