BACKGROUND: Validation of magnetic resonance imaging (MRI) and development of guidelines for the delineation of the gross tumor volume (GTV) is of utmost importance to benefit from the visibility of anatomical details on MR images and to achieve an accurate GTV delineation. In the ideal situation, the GTV delineation corresponds to the histopathologically determined 'true tumor volume'. Consequently, we developed guidelines for GTV delineation of laryngeal and hypopharyngeal tumors on MRI and determined the accuracy of the resulting delineation of the tumor outline on histopathology as gold standard. MATERIAL AND METHODS: Twenty-seven patients with T3 or T4 laryngeal/hypopharyngeal cancer underwent a MRI scan before laryngectomy. Hematoxylin and eosin sections were obtained from surgical specimens and tumor was delineated by one pathologist. GTV was delineated on MR images by three independent observers in two sessions. The first session (del1) was performed according to clinical practice. In the second session (del2) guidelines were used. The reconstructed specimen was registered to the MR images for comparison of the delineated GTVs to the tumor on histopathology. Volumes and overlap parameters were analyzed. A target margin needed to assure tumor coverage was determined. RESULTS: The median GTVs (del1: 19.4 cm3, del2: 15.8 cm3) were larger than the tumor volume on pathology (10.5 cm3). Comparable target margins were needed for both delineation sessions to assure tumor coverage. By adding these margins to the GTVs, the target volumes for del1 (median: 81.3 cm3) were significantly larger than for del2 (median: 64.2 cm3) (p ≤ 0.0001) with similar tumor coverage. CONCLUSIONS: In clinical radiotherapy practice, the delineated GTV on MRI is twice as large as the tumor volume. Validated delineation guidelines lead to a significant decrease in the overestimation of the tumor volume.
BACKGROUND: Validation of magnetic resonance imaging (MRI) and development of guidelines for the delineation of the gross tumor volume (GTV) is of utmost importance to benefit from the visibility of anatomical details on MR images and to achieve an accurate GTV delineation. In the ideal situation, the GTV delineation corresponds to the histopathologically determined 'true tumor volume'. Consequently, we developed guidelines for GTV delineation of laryngeal and hypopharyngeal tumors on MRI and determined the accuracy of the resulting delineation of the tumor outline on histopathology as gold standard. MATERIAL AND METHODS: Twenty-seven patients with T3 or T4 laryngeal/hypopharyngeal cancer underwent a MRI scan before laryngectomy. Hematoxylin and eosin sections were obtained from surgical specimens and tumor was delineated by one pathologist. GTV was delineated on MR images by three independent observers in two sessions. The first session (del1) was performed according to clinical practice. In the second session (del2) guidelines were used. The reconstructed specimen was registered to the MR images for comparison of the delineated GTVs to the tumor on histopathology. Volumes and overlap parameters were analyzed. A target margin needed to assure tumor coverage was determined. RESULTS: The median GTVs (del1: 19.4 cm3, del2: 15.8 cm3) were larger than the tumor volume on pathology (10.5 cm3). Comparable target margins were needed for both delineation sessions to assure tumor coverage. By adding these margins to the GTVs, the target volumes for del1 (median: 81.3 cm3) were significantly larger than for del2 (median: 64.2 cm3) (p ≤ 0.0001) with similar tumor coverage. CONCLUSIONS: In clinical radiotherapy practice, the delineated GTV on MRI is twice as large as the tumor volume. Validated delineation guidelines lead to a significant decrease in the overestimation of the tumor volume.
Authors: Mischa de Ridder; Cornelis P J Raaijmakers; Frank A Pameijer; Remco de Bree; Floris C J Reinders; Patricia A H Doornaert; Chris H J Terhaard; Marielle E P Philippens Journal: Cancers (Basel) Date: 2022-06-20 Impact factor: 6.575
Authors: Carlos E Cardenas; Sanne E Blinde; Abdallah S R Mohamed; Sweet Ping Ng; Cornelis Raaijmakers; Marielle Philippens; Alexis Kotte; Abrahim A Al-Mamgani; Irene Karam; David J Thomson; Jared Robbins; Kate Newbold; Clifton D Fuller; Chris Terhaard Journal: Int J Radiat Oncol Biol Phys Date: 2022-02-04 Impact factor: 8.013
Authors: Hans Ligtenberg; Tim Schakel; Jan Willem Dankbaar; Lilian N Ruiter; Boris Peltenburg; Stefan M Willems; Nicolien Kasperts; Chris H J Terhaard; Cornelis P J Raaijmakers; Marielle E P Philippens Journal: Cureus Date: 2018-04-11
Authors: Hans Ligtenberg; Stefan M Willems; Lilian N Ruiter; Elise Anne Jager; Chris H J Terhaard; Cornelis P J Raaijmakers; Marielle E P Philippens Journal: Clin Transl Radiat Oncol Date: 2018-07-11
Authors: Sweet Ping Ng; Carlos E Cardenas; Hesham Elhalawani; Courtney Pollard; Baher Elgohari; Penny Fang; Mohamed Meheissen; Nandita Guha-Thakurta; Houda Bahig; Jason M Johnson; Mona Kamal; Adam S Garden; Jay P Reddy; Shirley Y Su; Renata Ferrarotto; Steven J Frank; G Brandon Gunn; Amy C Moreno; David I Rosenthal; Clifton D Fuller; Jack Phan Journal: Phys Imaging Radiat Oncol Date: 2020-04-29
Authors: Ruta Zukauskaite; Christopher N Rumley; Christian R Hansen; Michael G Jameson; Yuvnik Trada; Jørgen Johansen; Niels Gyldenkerne; Jesper G Eriksen; Farhannah Aly; Rasmus L Christensen; Mark Lee; Carsten Brink; Lois Holloway Journal: Clin Transl Radiat Oncol Date: 2022-08-06
Authors: Sophie E Vollenbrock; Marlies E Nowee; Francine E M Voncken; Alexis N T J Kotte; Lucas Goense; Peter S N van Rossum; Astrid L H M W van Lier; Stijn W Heijmink; Annemarieke Bartels-Rutten; Frank J Wessels; Berthe M P Aleman; Luc Dewit; Linda G W Kerkmeijer; Edwin P M Jansen; Martijn Intven; Irene M Lips; Gert J Meijer; Jasper Nijkamp Journal: Adv Radiat Oncol Date: 2019-04-24