P Velloso1, C Piccinato2, Y Ferrão3, E Aliende Perin2, R Cesar4, L Fontenelle5, A G Hounie2, M C do Rosário2. 1. Child and Adolescent Psychiatry Unit (UPIA), Department of Psychiatry, Federal University of São Paulo, São Paulo, Brazil; Obsessive-Compulsive Spectrum Disorder Research Consortium (C-TOC), Brazil. Electronic address: patvelloso@gmail.com. 2. Child and Adolescent Psychiatry Unit (UPIA), Department of Psychiatry, Federal University of São Paulo, São Paulo, Brazil; Obsessive-Compulsive Spectrum Disorder Research Consortium (C-TOC), Brazil. 3. Obsessive-Compulsive Spectrum Disorder Research Consortium (C-TOC), Brazil; Department of Psychiatry, Health Sciences Federal University of Porto Alegre, Porto Alegre, Brazil. 4. Obsessive-Compulsive Spectrum Disorder Research Consortium (C-TOC), Brazil. 5. Obsessive-Compulsive Spectrum Disorder Research Consortium (C-TOC), Brazil; Department of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Abstract
BACKGROUND: Obsessive-compulsive disorder (OCD) has a chronic course leading to huge impact in the patient's functioning. Suicidal thoughts and attempts are much more frequent in OCD subjects than once thought before. AIM: To empirically investigate whether the suicidal phenomena could be analyzed as a suicidality severity continuum and its association with obsessive-compulsive (OC) symptom dimensions and quality of life (QoL), in a large OCD sample. METHODS: Cross-sectional study with 548 patients diagnosed with OCD according to the DSM-IV criteria, interviewed in the Brazilian OCD Consortium (C-TOC) sites. Patients were evaluated by OCD experts using standardized instruments including: Yale-Brown Obsessive-Compulsive Scale (YBOCS); Dimensional Yale-Brown Obsessive-Compulsive Scale (DYBOCS); Beck Depression and Anxiety Inventories; Structured Clinical Interview for DSM-IV (SCID); and the SF-36 QoL Health Survey. RESULTS: There were extremely high correlations between all the suicidal phenomena. OCD patients with suicidality had significantly lower QoL, higher severity in the "sexual/religious", "aggression" and "symmetry/ordering" OC symptom dimensions, higher BDI and BA scores and a higher frequency of suicide attempts in a family member. In the regression analysis, the factors that most impacted suicidality were the sexual dimension severity, the SF-36 QoL Mental Health domain, the severity of depressive symptoms and a relative with an attempted suicide history. CONCLUSIONS: Suicidality could be analyzed as a severity continuum and patients should be carefully monitored since they present with suicidal ideation. Lower QoL scores, higher scores on the sexual dimension and a family history of suicide attempts should be considered as risk factors for suicidality among OCD patients.
BACKGROUND:Obsessive-compulsive disorder (OCD) has a chronic course leading to huge impact in the patient's functioning. Suicidal thoughts and attempts are much more frequent in OCD subjects than once thought before. AIM: To empirically investigate whether the suicidal phenomena could be analyzed as a suicidality severity continuum and its association with obsessive-compulsive (OC) symptom dimensions and quality of life (QoL), in a large OCD sample. METHODS: Cross-sectional study with 548 patients diagnosed with OCD according to the DSM-IV criteria, interviewed in the Brazilian OCD Consortium (C-TOC) sites. Patients were evaluated by OCD experts using standardized instruments including: Yale-Brown Obsessive-Compulsive Scale (YBOCS); Dimensional Yale-Brown Obsessive-Compulsive Scale (DYBOCS); Beck Depression and Anxiety Inventories; Structured Clinical Interview for DSM-IV (SCID); and the SF-36 QoL Health Survey. RESULTS: There were extremely high correlations between all the suicidal phenomena. OCDpatients with suicidality had significantly lower QoL, higher severity in the "sexual/religious", "aggression" and "symmetry/ordering" OC symptom dimensions, higher BDI and BA scores and a higher frequency of suicide attempts in a family member. In the regression analysis, the factors that most impacted suicidality were the sexual dimension severity, the SF-36 QoL Mental Health domain, the severity of depressive symptoms and a relative with an attempted suicide history. CONCLUSIONS: Suicidality could be analyzed as a severity continuum and patients should be carefully monitored since they present with suicidal ideation. Lower QoL scores, higher scores on the sexual dimension and a family history of suicide attempts should be considered as risk factors for suicidality among OCDpatients.
Authors: Lily A Brown; Emily Wakschal; Stefanie Russman-Block; Christina L Boisseau; Maria C Mancebo; Jane L Eisen; Steven A Rasmussen Journal: J Affect Disord Date: 2018-11-13 Impact factor: 4.839
Authors: Vahid Khosravani; Seyed Mehdi Samimi Ardestani; Farangis Sharifi Bastan; Dean McKay; Gordon J G Asmundson Journal: Clin Psychol Psychother Date: 2021-05-05
Authors: Georgina Krebs; David Mataix-Cols; Frühling Rijsdijk; Christian Rück; Paul Lichtenstein; Sebastian Lundström; Henrik Larsson; Thalia C Eley; Lorena Fernández de la Cruz Journal: J Affect Disord Date: 2020-11-02 Impact factor: 4.839
Authors: Anna Sidorchuk; Ralf Kuja-Halkola; Bo Runeson; Paul Lichtenstein; Henrik Larsson; Christian Rück; Brian M D'Onofrio; David Mataix-Cols; Lorena Fernández de la Cruz Journal: Mol Psychiatry Date: 2019-04-08 Impact factor: 15.992
Authors: Thanh Phuong Anh Truong; Briana Applewhite; Annie Heiderscheit; Hubertus Himmerich Journal: Int J Environ Res Public Health Date: 2021-11-10 Impact factor: 3.390