Joseph J Shaffer1, Michael J Peterson1, Mary Agnes McMahon2, Joshua Bizzell3, Vince Calhoun4, Theo G M van Erp5, Judith M Ford6, John Lauriello7, Kelvin O Lim8, Dara S Manoach9, Sarah C McEwen10, Daniel H Mathalon6, Daniel O'Leary11, Steven G Potkin12, Adrian Preda13, Jessica Turner14, Jim Voyvodic15, Cynthia G Wible16, Aysenil Belger3. 1. Department of Psychiatry, University of North Carolina, Chapel Hill, N.C., USA. 2. Colorado Clinical and Translational Sciences Institute, University of Colorado, Denver, Colo., USA. 3. Department of Psychiatry, University of North Carolina, Chapel Hill, N.C., USA; Duke/University of North Carolina Brain Imaging and Analysis Center, Durham, N.C., USA. 4. The Mind Research Network, University of New Mexico, Albuquerque, N. Mex., USA; Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, N. Mex., USA. 5. Departments of Psychiatry and Human Behavior, University of California Irvine, Irvine, Calif., USA. 6. Department of Psychiatry, University of California San Francisco, San Francisco, Calif., USA. 7. Department of Psychiatry, University of Missouri, Columbia, Mo., USA. 8. Department of Psychiatry, University of Minnesota, Minneapolis, Minn., USA. 9. Department of Psychiatry, Massachusetts General Hospital, Charlestown, Mass., USA. 10. Department of Psychology, University of California Los Angeles, Los Angeles, Calif., USA. 11. Department of Neuroscience, University of Iowa, Iowa City, Iowa, USA. 12. Departments of Psychiatry, University of California Irvine, Irvine, Calif., USA; Department of Psychiatry, University of California San Francisco, San Francisco, Calif., USA. 13. Departments of Psychiatry, University of California Irvine, Irvine, Calif., USA. 14. Department of Psychology, Georgia State University, Atlanta, Ga., USA. 15. Duke/University of North Carolina Brain Imaging and Analysis Center, Durham, N.C., USA. 16. Department of Psychiatry, Harvard Medical School, Boston, Mass., USA; Department of Psychiatry, VA Medical Center Brockton, Brockton, Mass., USA.
Abstract
BACKGROUND: The negative symptoms of schizophrenia include deficits in emotional expression and motivation. These deficits are stable over the course of illness and respond poorly to current medications. Previous studies have focused on negative symptoms as a single category; however, individual symptoms might be related to separate neurological disturbances. We analyzed data from the Functional Biomedical Informatics Research Network dataset to explore the relationship between individual negative symptoms and functional brain activity during an auditory oddball task. METHODS: Functional magnetic resonance imaging was conducted on 89 schizophrenia patients and 106 healthy controls during a two-tone auditory oddball task. Blood oxygenation level-dependent (BOLD) signal during the target tone was correlated with severity of five negative symptom domains from the Scale for the Assessment of Negative Symptoms. RESULTS: The severity of alogia, avolition/apathy and anhedonia/asociality was negatively correlated with BOLD activity in distinct sets of brain regions associated with processing of the target tone, including basal ganglia, thalamus, insular cortex, prefrontal cortex, posterior cingulate and parietal cortex. CONCLUSIONS: Individual symptoms were related to different patterns of functional activation during the oddball task, suggesting that individual symptoms might arise from distinct neural mechanisms. This work has potential to inform interventions that target these symptom-related neural disruptions.
BACKGROUND: The negative symptoms of schizophrenia include deficits in emotional expression and motivation. These deficits are stable over the course of illness and respond poorly to current medications. Previous studies have focused on negative symptoms as a single category; however, individual symptoms might be related to separate neurological disturbances. We analyzed data from the Functional Biomedical Informatics Research Network dataset to explore the relationship between individual negative symptoms and functional brain activity during an auditory oddball task. METHODS: Functional magnetic resonance imaging was conducted on 89 schizophrenia patients and 106 healthy controls during a two-tone auditory oddball task. Blood oxygenation level-dependent (BOLD) signal during the target tone was correlated with severity of five negative symptom domains from the Scale for the Assessment of Negative Symptoms. RESULTS: The severity of alogia, avolition/apathy and anhedonia/asociality was negatively correlated with BOLD activity in distinct sets of brain regions associated with processing of the target tone, including basal ganglia, thalamus, insular cortex, prefrontal cortex, posterior cingulate and parietal cortex. CONCLUSIONS: Individual symptoms were related to different patterns of functional activation during the oddball task, suggesting that individual symptoms might arise from distinct neural mechanisms. This work has potential to inform interventions that target these symptom-related neural disruptions.
Entities:
Keywords:
Auditory oddball; Functional Biomedical Informatics Research Network; Functional magnetic resonance imaging; Negative symptoms; Schizophrenia
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