| Literature DB >> 2760617 |
P Davidsson1, P Fredman, V P Collins, H von Holst, J E Mänsson, L Svennerholm.
Abstract
The ganglioside composition in meningioma specimens from 20 patients was analyzed to find potential meningioma-associated structures. The characterization was performed by immunological staining with specific monoclonal antibodies to ganglioside antigens and fast atom bombardment-mass spectrometry. The major gangliosides were GM3 and GD3, and most of the meningioma specimens could be divided into a "GM3-rich" or a "GD3-rich" group. Gangliosides of the gangliotetraose series were represented by GM1, GD1a, GD1b, and GT1b, which were found in minor amounts in all the specimens. The ratios of GM1/GD1a and GD1a/GD1b differed from that in normal brain, and therefore existence of this series could not be explained by contamination with brain material. Ganglioside 3'-isoLM1, found in human malignant glioma, could not be detected in any meningioma specimen.Entities:
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Year: 1989 PMID： 2760617 DOI： 10.1111/j.1471-4159.1989.tb11761.x
Source DB: PubMed Journal: J Neurochem ISSN： 0022-3042 Impact factor: 5.372