Shehab Mahmoud Abd El-Kader1, Mohammed H Saiem Al-Dahr2. 1. Department of Physical Therapy, Faculty of Applied Medical Sciences, King Abdulaziz University. 2. Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University.
Abstract
BACKGROUND: Although postmenopausal associated disorders are important public health problems worldwide, to date limited studies evaluated the endothelial function and systemic inflammation response to weight loss in obese postmenopausal women. OBJECTIVE: This study was done to evaluate the endothelial function and systemic inflammation response to weight loss in obese postmenopausal Saudi women. MATERIAL AND METHODS:Eighty postmenopausal obese Saudi women (mean age 52.64±6.13 year) participated in two groups: Group (A) received aerobic exercise on treadmill and diet whereas, group (B) received no intervention. Markers of inflammation and endothelial function were measured before and after 3 months at the end of the study. RESULTS: The values of body mass index(BMI), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), inter-cellular adhesion molecule (ICAM-1), vascular cell adhesion molecule (VCAM-1) and plasminogen activator inhibitor-1 activity (PAI-1:Ac) were significantly decreased in group (A), while changes were not significant in group (B). Also, there were significant differences between mean levels of the investigated parameters in group (A) and group (B) after treatment. CONCLUSION:Weight loss ameliorates inflammatory cytokines and markers of endothelial function in obese postmenopausal Saudi women.
RCT Entities:
BACKGROUND: Although postmenopausal associated disorders are important public health problems worldwide, to date limited studies evaluated the endothelial function and systemic inflammation response to weight loss in obese postmenopausal women. OBJECTIVE: This study was done to evaluate the endothelial function and systemic inflammation response to weight loss in obese postmenopausal Saudi women. MATERIAL AND METHODS: Eighty postmenopausal obese Saudi women (mean age 52.64±6.13 year) participated in two groups: Group (A) received aerobic exercise on treadmill and diet whereas, group (B) received no intervention. Markers of inflammation and endothelial function were measured before and after 3 months at the end of the study. RESULTS: The values of body mass index(BMI), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), inter-cellular adhesion molecule (ICAM-1), vascular cell adhesion molecule (VCAM-1) and plasminogen activator inhibitor-1 activity (PAI-1:Ac) were significantly decreased in group (A), while changes were not significant in group (B). Also, there were significant differences between mean levels of the investigated parameters in group (A) and group (B) after treatment. CONCLUSION:Weight loss ameliorates inflammatory cytokines and markers of endothelial function in obese postmenopausal Saudi women.
Authors: Merethe H Rokling-Andersen; Janne E Reseland; Marit B Veierød; Sigmund A Anderssen; David R Jacobs; Petter Urdal; John-Olov Jansson; Christian A Drevon Journal: Am J Clin Nutr Date: 2007-11 Impact factor: 7.045
Authors: Inga E Schjerve; Gjertrud A Tyldum; Arnt E Tjønna; Tomas Stølen; Jan P Loennechen; Harald E M Hansen; Per M Haram; Garreth Heinrich; Anja Bye; Sonia M Najjar; Godfrey L Smith; Stig A Slørdahl; Ole J Kemi; Ulrik Wisløff Journal: Clin Sci (Lond) Date: 2008-11 Impact factor: 6.124
Authors: Cassandra E Forsythe; Stephen D Phinney; Maria Luz Fernandez; Erin E Quann; Richard J Wood; Doug M Bibus; William J Kraemer; Richard D Feinman; Jeff S Volek Journal: Lipids Date: 2007-11-29 Impact factor: 1.880
Authors: Raffaele Marfella; Katherine Esposito; Mario Siniscalchi; Federico Cacciapuoti; Francesco Giugliano; Domenico Labriola; Myriam Ciotola; Carmen Di Palo; Lucio Misso; Dario Giugliano Journal: Diabetes Care Date: 2004-01 Impact factor: 19.112
Authors: Lisa Tussing-Humphreys; Melissa Lamar; Andrew McLeod; Linda Schiffer; Lara Blumstein; Roxanne Dakers; Aimee Karstens; Nefertiti Oji Njideka Hemphill; Desmona Strahan; Leilah Siegel; Jennifer Sanchez Flack; Mirjana Antonic; Leo Restrepo; Michael Berbaum; Marian Fitzgibbon Journal: Prev Med Rep Date: 2022-08-19
Authors: Victoria Salem; Noara AlHusseini; Habeeb Ibrahim Abdul Razack; Anastasia Naoum; Omar T Sims; Saleh A Alqahtani Journal: Obes Rev Date: 2022-03-26 Impact factor: 10.867