INTRODUCTION: Previous studies had enlisted renal medullary carcinoma (RMC) as the seventh nephropathy in sickle cell disease (SCD). Clinical experience has contradicted this claim and this study is targeted at refuting or supporting this assumption. OBJECTIVE: To estimate the prevalence of RMC and describe other renal complications in SCD. MATERIALS AND METHODS: 14 physicians (haematologists and urologists) in 11 tertiary institutions across the country were collated from patients' case notes and hospital SCD registers. RESULTS: Of the 3,596 registered sickle patients, 2 (0.056%) had been diagnosed with RMC over a ten year period, thereby giving an estimated prevalence rate of 5.6 per 100,000. The most common renal complication reported by the attending physicians was chronic kidney disease (CKD). The frequency of routine renal screening for SCD patients varied widely between centres - most were done at diagnosis, annually or bi-annually. CONCLUSION: The ten year prevalence of RMC in Nigerian SCD patients was determined to be 5.6 (estimated incidence of 0.56). RMC is not more common in SCD patients and therefore cannot be regarded as a "Seventh Sickle nephropathy". Most of the managing physicians reported that the commonest nephropathy observed in their SCD patients was chronic kidney disease.
INTRODUCTION: Previous studies had enlisted renal medullary carcinoma (RMC) as the seventh nephropathy in sickle cell disease (SCD). Clinical experience has contradicted this claim and this study is targeted at refuting or supporting this assumption. OBJECTIVE: To estimate the prevalence of RMC and describe other renal complications in SCD. MATERIALS AND METHODS: 14 physicians (haematologists and urologists) in 11 tertiary institutions across the country were collated from patients' case notes and hospital SCD registers. RESULTS: Of the 3,596 registered sickle patients, 2 (0.056%) had been diagnosed with RMC over a ten year period, thereby giving an estimated prevalence rate of 5.6 per 100,000. The most common renal complication reported by the attending physicians was chronic kidney disease (CKD). The frequency of routine renal screening for SCDpatients varied widely between centres - most were done at diagnosis, annually or bi-annually. CONCLUSION: The ten year prevalence of RMC in Nigerian SCDpatients was determined to be 5.6 (estimated incidence of 0.56). RMC is not more common in SCDpatients and therefore cannot be regarded as a "Seventh Sickle nephropathy". Most of the managing physicians reported that the commonest nephropathy observed in their SCDpatients was chronic kidney disease.
Authors: Ruta Gupta; Athanase Billis; Rajal B Shah; Holger Moch; Adeboye O Osunkoya; Wolfram Jochum; Ondrej Hes; Carlos E Bacchi; Marilia G de Castro; Donna E Hansel; Ming Zhou; Mahesha Vankalakunti; Paulo G Salles; Rafael A Cabrera; Allen M Gown; Mahul B Amin Journal: Am J Surg Pathol Date: 2012-09 Impact factor: 6.394
Authors: Kathryn E Beckermann; Deva Sharma; Shruti Chaturvedi; Pavlos Msaouel; Miguel R Abboud; Yves Allory; Franck Bourdeaut; Julien Calderaro; Aguirre A de Cubas; Vimal K Derebail; Andrew L Hong; Rakhi P Naik; Gabriel G Malouf; Elizabeth A Mullen; Victor E Reuter; Charles W M Roberts; Cheryl L Walker; Christopher G Wood; Michael R DeBaun; Hendrik Van Poppel; Nizar M Tannir; W Kimryn Rathmell Journal: J Oncol Pract Date: 2017-07 Impact factor: 3.840