Literature DB >> 27605485

Tandem Difluoroalkylation-Arylation of Enamides Catalyzed by Nickel.

Ji-Wei Gu1, Qiao-Qiao Min1, Ling-Chao Yu1, Xingang Zhang2.   

Abstract

A nickel-catalyzed three-component reaction for the synthesis of difluoroalkylated compounds through tandem difluoroalkylation-arylation of enamides has been developed. The reaction tolerates a variety of arylboronic acids and widely available difluoroalkyl bromides, and even the relatively inert substrate chlorodifluoroacetate. The significant advantages of this protocol are the low-cost nickel catalyst, synthetic convenience, excellent functional-group compatibility and high reaction efficiency.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  boron; cross-coupling; fluorine; nickel; synthetic methods

Year:  2016        PMID： 27605485     DOI： 10.1002/anie.201606458

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  29 in total

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10.  General Method for Enantioselective Three-Component Carboarylation of Alkenes Enabled by Visible-Light Dual Photoredox/Nickel Catalysis.

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