Tamim Rajjo1, Jehad Almasri1, Alaa Al Nofal1, Wigdan Farah1, Mouaz Alsawas1, Ahmed T Ahmed1, Khaled Mohammed1, Amrit Kanwar1, Noor Asi1, Zhen Wang1, Larry J Prokop1, Mohammad Hassan Murad1. 1. Division of Preventive, Occupational, and Aerospace Medicine (T.R., J.A., W.F., M.A., A.A., K.M., N.A., Z.W., M.H.M.), Mayo Clinic, Rochester, Minnesota 55902; Evidence-Based Practice Center (J.A., W.F., M.A., A.A., K.M., N.A., Z.W., M.H.M.), Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota 55905; Pediatric Endocrinology (A.A.N.), Sanford Children's Specialty Clinic, University of South Dakota, Sioux Falls, South Dakota 57105; University of Iowa Carver College of Medicine (A.K.), Iowa City, Iowa 52242; and Library Public Services, Mayo Clinic (L.J.P.), Rochester, Minnesota 55902.
Abstract
BACKGROUND: Excess body weight in children is associated with multiple immediate and long-term medical comorbidities. We aimed to identify the degree of reduction in excess body weight associated with cardiometabolic changes (lipid panel, liver function tests, systolic blood pressure (SBP), diastolic blood pressure, glycosylated hemoglobin, and fasting blood glucose) in overweight and obese children. METHODS: We conducted a comprehensive search of MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, and Scopus through February 12, 2015. We included randomized controlled trials and cohort studies that evaluated interventions to treat pediatric obesity (medication, surgery, lifestyle, and community-based interventions) with ≥ a 6-month follow-up. We used a random effects meta-regression approach to assess the association between body mass index (BMI)/weight and cardiometabolic changes. RESULTS: We included 42 studies (37 randomized controlled trials and five cohorts) enrolling 3807 children (mean age, 12.2 years; weight, 74.7 kg; and BMI, 31.7 kg/m2). Studies had overall moderate to low risk of bias. A 1-mm Hg decrease in SBP was significantly associated with a decrease of 0.16 kg/m2 (P = .04) in BMI. A 1-mg/dL increase in HDL was significantly associated with a 0.74-kg decrease in weight (P = .02). A 1-mg/dL decrease in triglycerides was significantly associated with a 0.1-kg decrease in weight (P = .03). The remaining associations were not statistically significant. CONCLUSIONS: Weight reduction in children is associated with significant changes in several cardiometabolic outcomes, particularly HDL, SBP, and triglycerides. The magnitude of improvement may help in setting expectations and may inform shared decision-making and counseling.
BACKGROUND: Excess body weight in children is associated with multiple immediate and long-term medical comorbidities. We aimed to identify the degree of reduction in excess body weight associated with cardiometabolic changes (lipid panel, liver function tests, systolic blood pressure (SBP), diastolic blood pressure, glycosylated hemoglobin, and fasting blood glucose) in overweight and obesechildren. METHODS: We conducted a comprehensive search of MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, and Scopus through February 12, 2015. We included randomized controlled trials and cohort studies that evaluated interventions to treat pediatric obesity (medication, surgery, lifestyle, and community-based interventions) with ≥ a 6-month follow-up. We used a random effects meta-regression approach to assess the association between body mass index (BMI)/weight and cardiometabolic changes. RESULTS: We included 42 studies (37 randomized controlled trials and five cohorts) enrolling 3807 children (mean age, 12.2 years; weight, 74.7 kg; and BMI, 31.7 kg/m2). Studies had overall moderate to low risk of bias. A 1-mm Hg decrease in SBP was significantly associated with a decrease of 0.16 kg/m2 (P = .04) in BMI. A 1-mg/dL increase in HDL was significantly associated with a 0.74-kg decrease in weight (P = .02). A 1-mg/dL decrease in triglycerides was significantly associated with a 0.1-kg decrease in weight (P = .03). The remaining associations were not statistically significant. CONCLUSIONS: Weight reduction in children is associated with significant changes in several cardiometabolic outcomes, particularly HDL, SBP, and triglycerides. The magnitude of improvement may help in setting expectations and may inform shared decision-making and counseling.
Authors: Jennifer Cohen; Shirley Alexander; Michelle Critekos; Sarah P Garnett; Alison J Hayes; Tim Shaw; Kyra A Sim; Louise A Baur Journal: BMC Health Serv Res Date: 2018-06-07 Impact factor: 2.655
Authors: Stefan Sebastian Busnatu; Liviu Ionut Serbanoiu; Andreea Elena Lacraru; Catalina Liliana Andrei; Cosmina Elena Jercalau; Marilena Stoian; Anca Stoian Journal: Healthcare (Basel) Date: 2022-01-01