| Literature DB >> 27603408 |
Feng Gao1,2,3,4, Hongyu Chu2,3, Jianjun Li5,2,3,4, Mingliang Yang1,2,3,4, Liangjie DU1,2,3,4, Jun Li2,3, Liang Chen2,3, Degang Yang2,3, Hong Zhang2,3, Chetwyn Chan6.
Abstract
INTRODUCTION: The evidence regarding efficiency of repetitive transcranial magnetic stimulation (rTMS) on relief of neuropathic pain (NP) in patients with prior spinal cord injury (SCI) is controversial. The current meta-analysis aimed to assess the efficacy of rTMS in pain relieve in patients suffering from SCI associated NP. EVIDENCE ACQUISITION: Medline, PubMed, Cochrane Database, EMBASE, Google Scholar databases were searched for clinical studies on effects of rTMS treatment on NP caused by prior SCI published before March 14th, 2016 with various combinations of following key words: "transcranial magnetic stimulation," "spinal injury," "pain." Standardized difference in means with 95% confidence interval was calculated for the change of pain scores after rTMS or sham rTMS treatments. EVIDENCE SYNTHESIS: A total of two randomized controlled studies (RCTs) and 4 crossover RCTs were included in the present meta-analysis. The RCTs recruited a total of 27 patients. The crossover RCTs recruited a total of 100 patients. The combined standardized difference in means indicated that patients who received rTMS intervention had better pain relief than those who received sham rTMS intervention, however, the results did not reach statistical significance (standardized mean difference -0.607, 95% CI: -1.29 to 0.075, P=0.081).Entities:
Mesh：
Year: 2016 PMID： 27603408 DOI： 10.23736/S0390-5616.16.03809-1
Source DB: PubMed Journal: J Neurosurg Sci ISSN： 0390-5616 Impact factor: 2.279