BACKGROUND: Calcium hydroxylapatite with integral lidocaine, CaHA (+), received FDA approval in 2015 and CE mark approval in 2016. This formulation has been associated with significant pain reduction compared to CaHA. In a previous rheometry study, CaHA without lidocaine demonstrated higher viscosity and elasticity when compared with hyaluronic acid fillers. STUDY OBJECTIVE: To compare the rheological properties of CaHA (+) lidocaine to CaHA without lidocaine and to compare the rheological measures of CaHA (+) to 5 cross-linked hyaluronic acid (HA) fillers with integral 0.3% lidocaine.<br/> MATERIALS AND METHODS: The rheological properties of complex viscosity (η*) and elastic modulus (G') were measured for 2 types of CaHA fillers [CaHA without lidocaine and CaHA (+) with integral 0.3% lidocaine] and 5 HA fillers using an oscillation frequency sweep at a sheer stress of 5 pascal tau (Pa) and an interpolation of 0.7 Hz.<br/> RESULTS: CaHA with and without integral lidocaine demonstrate similar η* and G' measurements. CaHA with and without integral lidocaine demonstrates higher η* and G' compared with HA fillers with integral lidocaine.<br/> CONCLUSION: CaHA with integral lidocaine has a similar rheological profile to CaHA without lidocaine: the highest η* and G' compared with available HA fillers with integral lidocaine. <br /><br /> <em>J Drugs Dermatol.</em> 2016;15(9):1107-1110.
BACKGROUND:Calcium hydroxylapatite with integral lidocaine, CaHA (+), received FDA approval in 2015 and CE mark approval in 2016. This formulation has been associated with significant pain reduction compared to CaHA. In a previous rheometry study, CaHA without lidocaine demonstrated higher viscosity and elasticity when compared with hyaluronic acid fillers. STUDY OBJECTIVE: To compare the rheological properties of CaHA (+)lidocaine to CaHA without lidocaine and to compare the rheological measures of CaHA (+) to 5 cross-linked hyaluronic acid (HA) fillers with integral 0.3% lidocaine.<br/> MATERIALS AND METHODS: The rheological properties of complex viscosity (&eta;*) and elastic modulus (G') were measured for 2 types of CaHA fillers [CaHA without lidocaine and CaHA (+) with integral 0.3% lidocaine] and 5 HA fillers using an oscillation frequency sweep at a sheer stress of 5 pascal tau (Pa) and an interpolation of 0.7 Hz.<br/> RESULTS:CaHA with and without integral lidocaine demonstrate similar &eta;* and G' measurements. CaHA with and without integral lidocaine demonstrates higher &eta;* and G' compared with HA fillers with integral lidocaine.<br/> CONCLUSION:CaHA with integral lidocaine has a similar rheological profile to CaHA without lidocaine: the highest &eta;* and G' compared with available HA fillers with integral lidocaine. <br /><br /> <em>J Drugs Dermatol.</em> 2016;15(9):1107-1110.
Authors: Z Paul Lorenc; Jeanette M Black; Jessie S Cheung; Annie Chiu; Roberta Del Campo; Alan James Durkin; Miles Graivier; Jeremy B Green; Gideon P Kwok; Keith Marcus; Charalambos Babis Rammos; William Philip Werschler Journal: Aesthet Surg J Date: 2022-01-01 Impact factor: 4.283