Christopher P du Plooy1, Susan Malcolm-Smith2, Colleen M Adnams3, Dan J Stein4, Kirsten A Donald5. 1. Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa. 2. ACSENT Laboratory, Department of Psychology, University of Cape Town, Cape Town, South Africa. 3. Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa. 4. Department of Psychiatry and Mental Health, Groote Schuur Hospital, University of Cape Town, MRC Unit on Anxiety & Stress Disorders, Cape Town, South Africa. 5. 5Division of Developmental Paediatrics, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
Abstract
OBJECTIVE: This paper systematically reviews the literature on the effects of prenatal alcohol exposure (PAE) on episodic memory. Specifically, the review focuses on recurring questions of whether memory deficits are consistent across memory domains, whether the impairments are consistent across the stages of episodic memory, and whether the impairments are primary episodic memory impairments or secondary to a global performance deficit or a higher order deficit. METHOD: In total, 33 relevant studies were identified through searches on electronic databases. Journal articles were limited to those that included human subjects and that were published in English-language journals. RESULTS: The vast majority of reviewed studies examined memory in school-aged children and adolescents. Twenty-three studies examined verbal memory and 19 studies examined visual-spatial memory. Although all of the reviewed studies examined encoding of new material, only 10 studies examined retention of the learned material over time. Ten studies controlled for IQ, either statistically or with matched controls, when analyzing memory task performance. CONCLUSION: In general, studies show that PAE results in impaired verbal and visual-spatial episodic memory performance in affected individuals and these impairments are unlikely to be secondary to a global impairment. However, impairments on some memory tests are specific to the encoding stage, whereas retention is relatively spared; suggesting that the episodic memory deficit might be influenced, at least in part, by higher order cognitive processes.
OBJECTIVE: This paper systematically reviews the literature on the effects of prenatal alcohol exposure (PAE) on episodic memory. Specifically, the review focuses on recurring questions of whether memory deficits are consistent across memory domains, whether the impairments are consistent across the stages of episodic memory, and whether the impairments are primary episodic memory impairments or secondary to a global performance deficit or a higher order deficit. METHOD: In total, 33 relevant studies were identified through searches on electronic databases. Journal articles were limited to those that included human subjects and that were published in English-language journals. RESULTS: The vast majority of reviewed studies examined memory in school-aged children and adolescents. Twenty-three studies examined verbal memory and 19 studies examined visual-spatial memory. Although all of the reviewed studies examined encoding of new material, only 10 studies examined retention of the learned material over time. Ten studies controlled for IQ, either statistically or with matched controls, when analyzing memory task performance. CONCLUSION: In general, studies show that PAE results in impaired verbal and visual-spatial episodic memory performance in affected individuals and these impairments are unlikely to be secondary to a global impairment. However, impairments on some memory tests are specific to the encoding stage, whereas retention is relatively spared; suggesting that the episodic memory deficit might be influenced, at least in part, by higher order cognitive processes.
Authors: Donovan J Roediger; Alyssa M Krueger; Erik de Water; Bryon A Mueller; Christopher A Boys; Timothy J Hendrickson; Mariah J Schumacher; Sarah N Mattson; Kenneth L Jones; Kelvin O Lim; Jeffrey R Wozniak Journal: Neurotoxicol Teratol Date: 2020-11-21 Impact factor: 3.763
Authors: Nadine M Lindinger; Joseph L Jacobson; Christopher M R Warton; Susan Malcolm-Smith; Christopher D Molteno; Neil C Dodge; Frances Robertson; Ernesta M Meintjes; Sandra W Jacobson Journal: Alcohol Clin Exp Res Date: 2021-01-05 Impact factor: 3.455