Jun Li1, Shilong Wang2, Man Li1, Hui Xu2, Dandan Li1, Can Yin1, Jin Zhao1, Feng Li1,3. 1. Department of Pathology, Shihezi University School of Medicine & The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang 832002, China. 2. Department of Neurosurgery, the First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang 832002, China. 3. Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100000, China.
Abstract
AIM: This study aimed to conduct a meta-analysis to explore the association between SLC52A3 rs13042395 polymorphism and cancer risk. MATERIALS & METHODS: A comprehensive literature search was performed to confirm the relationship evaluated using STATA 12.0 software. RESULTS: Overall, SLC52A3 rs13042395 C>T polymorphism was associated with cancer risk in two genetic models (TT vs CC: odds ratio: 0.86; 95% CI: 0.80-0.93; p < 0.001, TT vs CC + CT: odds ratio: 0.88; 95% CI: 0.82-0.95; p = 0.001). Significant associations were found between SLC52A3 rs13042395 polymorphism and decreased cancer risk among esophageal cancer, Asians, female, normal BMI and old age groups. No significant associations were observed in alcohol and smoking groups. CONCLUSION: SLC52A3 rs13042395 C>T polymorphism might be a potential biomarker for cancer susceptibility.
AIM: This study aimed to conduct a meta-analysis to explore the association between SLC52A3rs13042395 polymorphism and cancer risk. MATERIALS & METHODS: A comprehensive literature search was performed to confirm the relationship evaluated using STATA 12.0 software. RESULTS: Overall, SLC52A3rs13042395 C>T polymorphism was associated with cancer risk in two genetic models (TT vs CC: odds ratio: 0.86; 95% CI: 0.80-0.93; p < 0.001, TT vs CC + CT: odds ratio: 0.88; 95% CI: 0.82-0.95; p = 0.001). Significant associations were found between SLC52A3rs13042395 polymorphism and decreased cancer risk among esophageal cancer, Asians, female, normal BMI and old age groups. No significant associations were observed in alcohol and smoking groups. CONCLUSION:SLC52A3rs13042395 C>T polymorphism might be a potential biomarker for cancer susceptibility.