Literature DB >> 27599630

End Points for Clinical Trials in Acute Kidney Injury.

David E Leaf1, Sushrut S Waikar2.   

Abstract

Acute kidney injury (AKI) is an increasingly common and feared complication in hospitalized patients. The selection of appropriate primary and secondary end points is critical to the design and eventual success of clinical trials aimed at preventing and treating AKI. In this article, we provide an overview of AKI definitions and suggestions on the rational selection of end points for clinical trials in various settings, including the prevention of contrast-induced AKI, prevention of cardiac surgery-associated AKI, treatment of established AKI, and treatment of dialysis-requiring AKI.
Copyright © 2016 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  AKDI definition; Acute kidney injury (AKI); acute renal failure (ARF); biomarker; clinical trial; end point; outcome; randomized controlled trial; study design

Mesh：

Year:  2016        PMID： 27599630      PMCID： PMC5182076          DOI： 10.1053/j.ajkd.2016.05.033

Source DB:  PubMed          Journal:  Am J Kidney Dis        ISSN： 0272-6386            Impact factor:   8.860


  52 in total

1.  Yes, AKI truly leads to CKD.

Authors:  Chi-yuan Hsu
Journal:  J Am Soc Nephrol       Date:  2012-04-12       Impact factor: 10.121

2.  Third universal definition of myocardial infarction.

Authors:  Kristian Thygesen; Joseph S Alpert; Allan S Jaffe; Maarten L Simoons; Bernard R Chaitman; Harvey D White; Kristian Thygesen; Joseph S Alpert; Harvey D White; Allan S Jaffe; Hugo A Katus; Fred S Apple; Bertil Lindahl; David A Morrow; Bernard R Chaitman; Peter M Clemmensen; Per Johanson; Hanoch Hod; Richard Underwood; Jeroen J Bax; Jeroen J Bonow; Fausto Pinto; Raymond J Gibbons; Keith A Fox; Dan Atar; L Kristin Newby; Marcello Galvani; Christian W Hamm; Barry F Uretsky; Ph Gabriel Steg; William Wijns; Jean-Pierre Bassand; Phillippe Menasche; Jan Ravkilde; E Magnus Ohman; Elliott M Antman; Lars C Wallentin; Paul W Armstrong; Maarten L Simoons; James L Januzzi; Markku S Nieminen; Mihai Gheorghiade; Gerasimos Filippatos; Russell V Luepker; Stephen P Fortmann; Wayne D Rosamond; Dan Levy; David Wood; Sidney C Smith; Dayi Hu; Jose-Luis Lopez-Sendon; Rose Marie Robertson; Douglas Weaver; Michal Tendera; Alfred A Bove; Alexander N Parkhomenko; Elena J Vasilieva; Shanti Mendis; Jeroen J Bax; Helmut Baumgartner; Claudio Ceconi; Veronica Dean; Christi Deaton; Robert Fagard; Christian Funck-Brentano; David Hasdai; Arno Hoes; Paulus Kirchhof; Juhani Knuuti; Philippe Kolh; Theresa McDonagh; Cyril Moulin; Bogdan A Popescu; Zeljko Reiner; Udo Sechtem; Per Anton Sirnes; Michal Tendera; Adam Torbicki; Alec Vahanian; Stephan Windecker; Joao Morais; Carlos Aguiar; Wael Almahmeed; David O Arnar; Fabio Barili; Kenneth D Bloch; Ann F Bolger; Hans Erik Botker; Biykem Bozkurt; Raffaele Bugiardini; Christopher Cannon; James de Lemos; Franz R Eberli; Edgardo Escobar; Mark Hlatky; Stefan James; Karl B Kern; David J Moliterno; Christian Mueller; Aleksandar N Neskovic; Burkert Mathias Pieske; Steven P Schulman; Robert F Storey; Kathryn A Taubert; Pascal Vranckx; Daniel R Wagner
Journal:  J Am Coll Cardiol       Date:  2012-09-05       Impact factor: 24.094

3.  Acute kidney injury, mortality, length of stay, and costs in hospitalized patients.

Authors:  Glenn M Chertow; Elisabeth Burdick; Melissa Honour; Joseph V Bonventre; David W Bates
Journal:  J Am Soc Nephrol       Date:  2005-09-21       Impact factor: 10.121

4.  The association of acute kidney injury in the critically ill and postdischarge outcomes: a cohort study*.

Authors:  Clare M Horkan; Steven W Purtle; Mallika L Mendu; Takuhiro Moromizato; Fiona K Gibbons; Kenneth B Christopher
Journal:  Crit Care Med       Date:  2015-02       Impact factor: 7.598

5.  High-dose furosemide for established ARF: a prospective, randomized, double-blind, placebo-controlled, multicenter trial.

Authors:  Félix Cantarovich; Badrudin Rangoonwala; Horst Lorenz; Matti Verho; Vincent L M Esnault
Journal:  Am J Kidney Dis       Date:  2004-09       Impact factor: 8.860

Review 6.  Biomarkers for the diagnosis and risk stratification of acute kidney injury: a systematic review.

Authors:  S G Coca; R Yalavarthy; J Concato; C R Parikh
Journal:  Kidney Int       Date:  2007-12-19       Impact factor: 10.612

7.  Minimal changes of serum creatinine predict prognosis in patients after cardiothoracic surgery: a prospective cohort study.

Authors:  Andrea Lassnigg; Daniel Schmidlin; Mohamed Mouhieddine; Lucas M Bachmann; Wilfred Druml; Peter Bauer; Michael Hiesmayr
Journal:  J Am Soc Nephrol       Date:  2004-06       Impact factor: 10.121

8.  A comparison of contemporary definitions of contrast nephropathy in patients undergoing percutaneous coronary intervention and a proposal for a novel nephropathy grading system.

Authors:  Kishore J Harjai; Amol Raizada; Chetan Shenoy; Sudhakar Sattur; Pamela Orshaw; Karl Yaeger; Judy Boura; Ali Aboufares; Daniel Sporn; Dwight Stapleton
Journal:  Am J Cardiol       Date:  2008-01-14       Impact factor: 2.778

9.  Remote ischemic preconditioning reduces myocardial and renal injury after elective abdominal aortic aneurysm repair: a randomized controlled trial.

Authors:  Ziad A Ali; Chris J Callaghan; Eric Lim; Ayyaz A Ali; S A Reza Nouraei; Asim M Akthar; Jonathan R Boyle; Kevin Varty; Rajesh K Kharbanda; David P Dutka; Michael E Gaunt
Journal:  Circulation       Date:  2007-09-11       Impact factor: 29.690

10.  Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury.

Authors:  Ravindra L Mehta; John A Kellum; Sudhir V Shah; Bruce A Molitoris; Claudio Ronco; David G Warnock; Adeera Levin
Journal:  Crit Care       Date:  2007       Impact factor: 9.097
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  6 in total

Review 1.  Preconditioning against renal ischaemia reperfusion injury: the failure to translate to the clinic.

Authors:  Dermot O'Kane; Graham S Baldwin; Damien M Bolton; Joseph J Ischia; Oneel Patel
Journal:  J Nephrol       Date:  2019-01-11       Impact factor: 3.902

2.  AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19.

Authors:  Shruti Gupta; Steven G Coca; Lili Chan; Michal L Melamed; Samantha K Brenner; Salim S Hayek; Anne Sutherland; Sonika Puri; Anand Srivastava; Amanda Leonberg-Yoo; Alexandre M Shehata; Jennifer E Flythe; Arash Rashidi; Edward J Schenck; Nitender Goyal; S Susan Hedayati; Rajany Dy; Anip Bansal; Ambarish Athavale; H Bryant Nguyen; Anitha Vijayan; David M Charytan; Carl E Schulze; Min J Joo; Allon N Friedman; Jingjing Zhang; Marie Anne Sosa; Eric Judd; Juan Carlos Q Velez; Mary Mallappallil; Roberta E Redfern; Amar D Bansal; Javier A Neyra; Kathleen D Liu; Amanda D Renaghan; Marta Christov; Miklos Z Molnar; Shreyak Sharma; Omer Kamal; Jeffery Owusu Boateng; Samuel A P Short; Andrew J Admon; Meghan E Sise; Wei Wang; Chirag R Parikh; David E Leaf
Journal:  J Am Soc Nephrol       Date:  2020-10-16       Impact factor: 10.121

3.  SEA-MAKE score as a tool for predicting major adverse kidney events in critically ill patients with acute kidney injury: results from the SEA-AKI study.

Authors:  Theerapon Sukmark; Nuttha Lumlertgul; Kearkiat Praditpornsilpa; Kriang Tungsanga; Somchai Eiam-Ong; Nattachai Srisawat
Journal:  Ann Intensive Care       Date:  2020-04-16       Impact factor: 6.925

4.  Sex-related differences in mortality, acute kidney injury, and respiratory failure among critically ill patients with COVID-19.

Authors:  Stephanie M Toth-Manikowski; Jillian Caldwell; Min Joo; Jinsong Chen; Natalie Meza; Jacob Bruinius; Shruti Gupta; Mary Hannan; Mustafa Kagalwalla; Samantha Madrid; Michal L Melamed; Esther Pacheco; Anand Srivastava; Christopher Viamontes; James P Lash; David E Leaf; Ana C Ricardo
Journal:  Medicine (Baltimore)       Date:  2021-12-17       Impact factor: 1.817

5.  Development and validation of outcome prediction models for acute kidney injury patients undergoing continuous renal replacement therapy.

Authors:  Bo Li; Yan Huo; Kun Zhang; Limin Chang; Haohua Zhang; Xinrui Wang; Leying Li; Zhenjie Hu
Journal:  Front Med (Lausanne)       Date:  2022-08-18

Review 6.  Prevention of Cardiac Surgery-Associated Acute Kidney Injury: A Review of Current Strategies.

Authors:  Kirolos A Jacob; David E Leaf
Journal:  Anesthesiol Clin       Date:  2019-09-21
  6 in total

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