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Literature DB >> 27599504

Zinc finger domain of Su(Hw) protein is required for the formation of functional Su(Hw)-dependent insulator complex.

A K Golovnin¹, V V Molodina², P G Georgiev², L S Melnikova².

Abstract

This study is devoted to clarifying the role of Mod(mdg4)-67.2 and Su(Hw) proteins in the interaction between Su(Hw)-dependent insulator complexes and identifying the specific domains of the Su(Hw) protein required for insulation or mutual neutralization of insulators. Using genetic techniques and experiments in yeast two-hybrid system, we have demonstrated that the zinc finger domain of the Su(Hw) protein is involved in forming a functional insulator complex and cannot be replaced with the DNA-binding domain of the GAL4 protein.

Entities: Gene Species

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Year: 2016 PMID： 27599504 DOI： 10.1134/S1607672916040049

Source DB: PubMed Journal: Dokl Biochem Biophys ISSN： 1607-6729 Impact factor: 0.788

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References

15 in total

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Authors: P K Geyer; V G Corces
Journal: Genes Dev Date: 1987-11 Impact factor: 11.361

Zinc finger domain of Su(Hw) protein is required for the formation of functional Su(Hw)-dependent insulator complex.

1. In-depth mutational analysis of the promyelocytic leukemia zinc finger BTB/POZ domain reveals motifs and residues required for biological and transcriptional functions.

2. Interaction between mutations in the suppressor of Hairy wing and modifier of mdg4 genes of Drosophila melanogaster affecting the phenotype of gypsy-induced mutations.

3. Interactions among the gypsy transposable element and the yellow and the suppressor of hairy-wing loci in Drosophila melanogaster.

4. Insulation of enhancer-promoter communication by a gypsy transposon insert in the Drosophila cut gene: cooperation between suppressor of hairy-wing and modifier of mdg4 proteins.

5. Loss of insulator activity by paired Su(Hw) chromatin insulators.

6. Genetic and molecular complexity of the position effect variegation modifier mod(mdg4) in Drosophila.

7. DNA bending is a determinant of binding specificity for a Drosophila zinc finger protein.

8. The centrosomal protein CP190 is a component of the gypsy chromatin insulator.

Review 9. The modifier of mdg4 locus in Drosophila: functional complexity is resolved by trans splicing.

10. Separate regulatory elements are responsible for the complex pattern of tissue-specific and developmental transcription of the yellow locus in Drosophila melanogaster.