Anna M Czarnecka1, Paweł Sobczuk1,2, Jan Korniluk1, Marta Spychalska1,2,3, Krzysztof Bogusz1,4, Anna Owczarek1,2,5, Anna Brodziak1,2, Dominika Labochka1,2, Barbara Moszczuk1,2, Cezary Szczylik1. 1. Department of Oncology, Military Institute of Medicine, Warsaw, Poland. 2. Second Faculty of Medicine, Medical University of Warsaw, Warsaw, Poland. 3. National Institute of Geriatrics, Rheumatology & Rehabilitation, Warsaw, Poland. 4. First Faculty of Medicine, Medical University of Warsaw, Warsaw, Poland. 5. Department of Internal Diseases & Hematology, Military Institute of Medicine, Warsaw, Poland.
Abstract
AIM: The study aim was to evaluate progression-free survival (PFS) and overall survival (OS) in patients with metastatic clear cell renal cell carcinoma on sunitinib (SU) and SU-everolimus treatment. PATIENTS & METHODS: After 7 years of enrollment and 9 years of follow-up, 193 consecutively presenting patients (151 men and 42 women) were treated. RESULTS: A total of 157 patients (81.3%) died and 36 patients (18.7%) survived. Median PFS in 193 SU-treated patients was 14.7 months and OS was 28.8 months. Median PFS was 13.98 months and median OS was 26.67 months in 175 patients treated with SU only or on SU-everolimus. CONCLUSION: The development of SU-induced hypothyroidism, hypertension, neutropenia and edema was a significant predictive and prognostic factor.
AIM: The study aim was to evaluate progression-free survival (PFS) and overall survival (OS) in patients with metastatic clear cell renal cell carcinoma on sunitinib (SU) and SU-everolimus treatment. PATIENTS & METHODS: After 7 years of enrollment and 9 years of follow-up, 193 consecutively presenting patients (151 men and 42 women) were treated. RESULTS: A total of 157 patients (81.3%) died and 36 patients (18.7%) survived. Median PFS in 193 SU-treated patients was 14.7 months and OS was 28.8 months. Median PFS was 13.98 months and median OS was 26.67 months in 175 patients treated with SU only or on SU-everolimus. CONCLUSION: The development of SU-induced hypothyroidism, hypertension, neutropenia and edema was a significant predictive and prognostic factor.
Authors: Łukasz Mielczarek; Anna Brodziak; Paweł Sobczuk; Maciej Kawecki; Agnieszka Cudnoch-Jędrzejewska; Anna M Czarnecka Journal: Cancer Chemother Pharmacol Date: 2021-03-25 Impact factor: 3.333