Carolien N H Abheiden1, Birgit S Blomjous1,2, Sylvia J Kroese3, Irene E M Bultink2, Ruth D E Fritsch-Stork3, A Titia Lely4, Marjon A de Boer1, Johanna I P de Vries1. 1. a Department of Obstetrics and Gynaecology , VU University Medical Center , Amsterdam , The Netherlands. 2. b Department of Rheumatology , Amsterdam Rheumatology and Immunology Center, VU University Medical Center , Amsterdam , The Netherlands. 3. c Department of Rheumatology , University Medical Center Utrecht , Utrecht , The Netherlands. 4. d Department of Obstetrics and Gynaecology , University Medical Center Utrecht , Utrecht , The Netherlands.
Abstract
OBJECTIVE: To relate anticoagulant use to pregnancy complications in women with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS). METHODS: All ongoing pregnancies, 184, in two Dutch tertiary centers between 2000 and 2015. RESULTS: LMWH and aspirin was prescribed in 15/109 SLE women without antiphospholipid antibodies (aPL), 5/14 with aPL, 11/13 with APS, 45/48 with primary APS. Main complications in the four treatment groups (no anticoagulant treatment, aspirin, LMWH, aspirin and LMWH) included hypertensive disorders of pregnancy (9.4%, 23.3%, 50%, 18.4%, respectively, p = 0.12) and preterm birth (16.7%, 34.3%, 75%, 36.8%, respectively, p < 0.001). CONCLUSION: Maternal and perinatal complications occurred frequently, despite LMWH and aspirin use.
OBJECTIVE: To relate anticoagulant use to pregnancy complications in women with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS). METHODS: All ongoing pregnancies, 184, in two Dutch tertiary centers between 2000 and 2015. RESULTS:LMWH and aspirin was prescribed in 15/109 SLEwomen without antiphospholipid antibodies (aPL), 5/14 with aPL, 11/13 with APS, 45/48 with primary APS. Main complications in the four treatment groups (no anticoagulant treatment, aspirin, LMWH, aspirin and LMWH) included hypertensive disorders of pregnancy (9.4%, 23.3%, 50%, 18.4%, respectively, p = 0.12) and preterm birth (16.7%, 34.3%, 75%, 36.8%, respectively, p < 0.001). CONCLUSION: Maternal and perinatal complications occurred frequently, despite LMWH and aspirin use.
Authors: Sylvia J Kroese; Carolien N H Abheiden; Birgit S Blomjous; Jacob M van Laar; Ronald W H M Derksen; Irene E M Bultink; Alexandre E Voskuyl; A Titia Lely; Marjon A de Boer; Johanna I P de Vries; Ruth D E Fritsch-Stork Journal: J Immunol Res Date: 2017-09-28 Impact factor: 4.818
Authors: Tatiana M Reshetnyak; Irina A Doroshkevich; Natalia V Seredavkina; Evgeny L Nasonov; Igor V Maev; Vasiliy I Reshetnyak Journal: Int J Rheumatol Date: 2019-05-05