| Literature DB >> 2759905 |
O Nakayama1, N Shigematsu, A Katayama, S Takase, S Kiyoto, M Hashimoto, M Kohsaka.
Abstract
On the basis of spectroscopic and chemical evidence, the structures of WS-9659 A and B isolated as inhibitors of testosterone 5 alpha-reductase from a Streptomyces have been established as 1 and 2, respectively. The reductase inhibitory activities of the derivatives 5 and 6, and degradation products 3 and 8 were considerably less active and substantially inactive, respectively.Entities:
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Year: 1989 PMID： 2759905 DOI： 10.7164/antibiotics.42.1230
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649