Isabel Madeira1, Maria Alice Bordallo2, Nádia Cristina Rodrigues3, Cecilia Carvalho4, Fernanda Gazolla5, Paulo Collett-Solberg2, Clarice Medeiros5, Ana Paula Bordallo5, Marcos Borges5, Claudia Monteiro5, Rebeca Ribeiro6. 1. Faculdade de Ciências Médicas, Departamento de Pediatria, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brasil. 2. Faculdade de Ciências Médicas, Departamento de Medicina Interna, UERJ, Rio de Janeiro, RJ, Brasil. 3. Faculdade de Ciências Médicas, Departamento de Tecnologias da Informação e Educação em Saúde, UERJ, Rio de Janeiro, RJ, Brasil. 4. Instituto de Nutrição, Departamento de Nutrição Aplicada, UERJ, Rio de Janeiro, RJ, Brasil. 5. Hospital Universitário Pedro Ernesto, Unidade Docente Assistencial de Endocrinologia e Metabologia, UERJ, Rio de Janeiro, RJ, Brasil. 6. Faculdade de Ciências Médicas, UERJ, Rio de Janeiro, RJ, Brasil.
Abstract
OBJECTIVE: Leptin has been suggested as a potential biomarker of cardiovascular risk. This paper aims to ascertain, based on a sample of prepubertal children, which serum leptin value best suited to identify metabolic syndrome (MS). SUBJECTS AND METHODS: This observational, cross-sectional study recruited children from the outpatient pediatrics clinic, with the purpose of validating serum leptin level cutoffs to identify MS. All obese and overweight children who met eligibility criteria were included in the study, as was a sample of normal-weight children. The sample underwent clinical assessment and blood fasting glucose, lipid profile, insulin, and leptin were measured. Sensitivity and specificity were estimated for each leptin measurement, using MS as the outcome. These values were used to construct a receiver operating characteristic (ROC) curve. The association between MS and leptin was assessed using logistic models to predict MS. RESULTS: A total of 65 normal weight, 46 overweight, and 164 obese children were analyzed (160 boys, 115 girls; age: 93.7 ± 17.8 months). The most appropriate leptin cutoff was 13.4 ng/mL (sensitivity 67.6%; specificity 68.9%; accuracy 72.1%). The logistic model indicated that leptin levels above 13.4 ng/dL were significantly associated with MS and that, for every 1 ng/dL increase in leptin levels, the odds of MS increase by 3% (p = 0.002; OR 1.03; 95% CI 1.01-1.05). CONCLUSIONS: Leptin may be a useful biomarker of cardiovascular risk in prepubertal children, with an optimal cutoff of 13.4 ng/mL. Identification of potential new risk markers for cardiovascular disease in children could contribute to the development of preventive strategies.
OBJECTIVE: Leptin has been suggested as a potential biomarker of cardiovascular risk. This paper aims to ascertain, based on a sample of prepubertal children, which serum leptin value best suited to identify metabolic syndrome (MS). SUBJECTS AND METHODS: This observational, cross-sectional study recruited children from the outpatient pediatrics clinic, with the purpose of validating serum leptin level cutoffs to identify MS. All obese and overweight children who met eligibility criteria were included in the study, as was a sample of normal-weight children. The sample underwent clinical assessment and blood fasting glucose, lipid profile, insulin, and leptin were measured. Sensitivity and specificity were estimated for each leptin measurement, using MS as the outcome. These values were used to construct a receiver operating characteristic (ROC) curve. The association between MS and leptin was assessed using logistic models to predict MS. RESULTS: A total of 65 normal weight, 46 overweight, and 164 obese children were analyzed (160 boys, 115 girls; age: 93.7 ± 17.8 months). The most appropriate leptin cutoff was 13.4 ng/mL (sensitivity 67.6%; specificity 68.9%; accuracy 72.1%). The logistic model indicated that leptin levels above 13.4 ng/dL were significantly associated with MS and that, for every 1 ng/dL increase in leptin levels, the odds of MS increase by 3% (p = 0.002; OR 1.03; 95% CI 1.01-1.05). CONCLUSIONS: Leptin may be a useful biomarker of cardiovascular risk in prepubertal children, with an optimal cutoff of 13.4 ng/mL. Identification of potential new risk markers for cardiovascular disease in children could contribute to the development of preventive strategies.
Authors: Ariane R de F Rocha; Núbia de S Morais; Silvia E Priore; Sylvia do C C Franceschini Journal: Inflammation Date: 2021-09-21 Impact factor: 4.092
Authors: Alberto Romano; Ester Del Vescovo; Serena Rivetti; Silvia Triarico; Giorgio Attinà; Stefano Mastrangelo; Palma Maurizi; Antonio Ruggiero Journal: J Pers Med Date: 2022-05-27
Authors: Eleni M Domouzoglou; Antonios P Vlahos; Vasileios K Cholevas; Michail I Papafaklis; Nikolaos Chaliasos; Ekaterini Siomou; Lampros K Michalis; Agathocles Tsatsoulis; Katerina K Naka Journal: Ann Pediatr Endocrinol Metab Date: 2021-05-17