| Literature DB >> 27598298 |
Na Luan1, Wen-Di Wei1, Ali Wang1, Xiu-Li Wu2, Yan Qi3, Jin-Jie Li1, Jian-Quan Zheng1, Xiao-Ya Shang1.
Abstract
Four new taraxastane-type triterpenoids acids 3β,22α-dihydroxy-20-taraxasten-30-oic acid (1), 3β-hydroxy-22-oxo-20-taraxasten-30-oic acid (2), 3-oxo-22α-hydroxy-20- taraxasten-30-oic acid (3), and 3β,19β-dihydroxy-20-taraxasten-30-oic acid (4) were isolated and characterized from Cirsium setosum (Willd.) MB. Their structures were determined by the combination of 1D and 2D NMR experiments ((1)H-(1)HCOSY, HSQC, HMBC and ROESY) and mass spectrometry. Compound 2 exhibited potent selective cytotoxicity against human ovarian cancer cell line A2780 with an IC50 value of 3.9 μM.Entities:
Keywords: Cirsium setosum; Compositae; absolute configuration; cytotoxic activities; taraxastane-type triterpenoids acids
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Year: 2016 PMID： 27598298 DOI： 10.1080/10286020.2016.1217519
Source DB: PubMed Journal: J Asian Nat Prod Res ISSN： 1028-6020 Impact factor: 1.569