Literature DB >> 27596705

Regulatory T cells in allergic diseases.

Magali Noval Rivas1, Talal A Chatila2.   

Abstract

The pathogenesis of allergic diseases entails an ineffective tolerogenic immune response to allergens. Regulatory T (Treg) cells play a key role in sustaining immune tolerance to allergens, yet mechanisms by which Treg cells fail to maintain tolerance in patients with allergic diseases are not well understood. We review current concepts and established mechanisms regarding how Treg cells regulate different components of allergen-triggered immune responses to promote and maintain tolerance. We will also discuss more recent advances that emphasize the "dual" functionality of Treg cells in patients with allergic diseases: how Treg cells are essential in promoting tolerance to allergens but also how a proallergic inflammatory environment can skew Treg cells toward a pathogenic phenotype that aggravates and perpetuates disease. These advances highlight opportunities for novel therapeutic strategies that aim to re-establish tolerance in patients with chronic allergic diseases by promoting Treg cell stability and function.
Copyright © 2016 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Asthma; IL-4; T(H)2 cells; food allergy; forkhead box P3; regulatory T cells

Mesh：

Substances：

Year:  2016        PMID： 27596705      PMCID： PMC5023156          DOI： 10.1016/j.jaci.2016.06.003

Source DB:  PubMed          Journal:  J Allergy Clin Immunol        ISSN： 0091-6749            Impact factor:   10.793


  150 in total

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Journal:  Immunity       Date:  2003-05       Impact factor: 31.745

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Journal:  Nature       Date:  2013-11-13       Impact factor: 49.962

Review 3.  The allergy epidemics: 1870-2010.

Authors:  Thomas A E Platts-Mills
Journal:  J Allergy Clin Immunol       Date:  2015-07       Impact factor: 10.793

4.  Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota.

Authors:  June L Round; Sarkis K Mazmanian
Journal:  Proc Natl Acad Sci U S A       Date:  2010-06-21       Impact factor: 11.205

5.  Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns.

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Journal:  Proc Natl Acad Sci U S A       Date:  2010-06-21       Impact factor: 11.205

6.  IL-25 and CD4(+) TH2 cells enhance type 2 innate lymphoid cell-derived IL-13 production, which promotes IgE-mediated experimental food allergy.

Authors:  Jee-Boong Lee; Chun-Yu Chen; Bo Liu; Luke Mugge; Pornpimon Angkasekwinai; Valeria Facchinetti; Chen Dong; Yong-Jun Liu; Marc E Rothenberg; Simon P Hogan; Fred D Finkelman; Yui-Hsi Wang
Journal:  J Allergy Clin Immunol       Date:  2015-11-10       Impact factor: 10.793

7.  Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity.

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Journal:  Nat Immunol       Date:  2011-12-04       Impact factor: 25.606

8.  An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells.

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Journal:  Nat Med       Date:  2016-08-01       Impact factor: 53.440

9.  Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma.

Authors:  Raffi Tachdjian; Clinton Mathias; Shadi Al Khatib; Paul J Bryce; Hong S Kim; Frank Blaeser; Brian D O'Connor; Danuta Rzymkiewicz; Andrew Chen; Michael J Holtzman; Gurjit K Hershey; Holger Garn; Hani Harb; Harald Renz; Hans C Oettgen; Talal A Chatila
Journal:  J Exp Med       Date:  2009-09-21       Impact factor: 14.307

10.  Transcription factor Foxp3 and its protein partners form a complex regulatory network.

Authors:  Dipayan Rudra; Paul deRoos; Ashutosh Chaudhry; Rachel E Niec; Aaron Arvey; Robert M Samstein; Christina Leslie; Scott A Shaffer; David R Goodlett; Alexander Y Rudensky
Journal:  Nat Immunol       Date:  2012-08-26       Impact factor: 25.606
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  100 in total

Review 1.  Tolerogenic vaccines: Targeting the antigenic and cytokine niches of FOXP3+ regulatory T cells.

Authors:  Mark D Mannie; Kayla B DeOca; Alexander G Bastian; Cody D Moorman
Journal:  Cell Immunol       Date:  2020-07-15       Impact factor: 4.868

2.  Semaphorin 4A Stabilizes Human Regulatory T Cell Phenotype via Plexin B1.

Authors:  Svetlana P Chapoval; Molly Hritzo; Xiulan Qi; Luca Tamagnone; Amit Golding; Achsah D Keegan
Journal:  Immunohorizons       Date:  2019-02

3.  Single-cell profiling of peanut-responsive T cells in patients with peanut allergy reveals heterogeneous effector TH2 subsets.

Authors:  David Chiang; Xintong Chen; Stacie M Jones; Robert A Wood; Scott H Sicherer; A Wesley Burks; Donald Y M Leung; Charuta Agashe; Alexander Grishin; Peter Dawson; Wendy F Davidson; Leah Newman; Robert Sebra; Miriam Merad; Hugh A Sampson; Bojan Losic; M Cecilia Berin
Journal:  J Allergy Clin Immunol       Date:  2018-01-31       Impact factor: 10.793

Review 4.  Cell-by-cell deciphering of T cells in allergic inflammation.

Authors:  Ting Wen; Marc E Rothenberg
Journal:  J Allergy Clin Immunol       Date:  2019-11       Impact factor: 10.793

Review 5.  Pathogenic CD4+ T cells in patients with asthma.

Authors:  Lyndsey M Muehling; Monica G Lawrence; Judith A Woodfolk
Journal:  J Allergy Clin Immunol       Date:  2017-04-22       Impact factor: 10.793

6.  Treatment of severe persistent asthma with IL-6 receptor blockade.

Authors:  Brittany Esty; Hani Harb; Lisa M Bartnikas; Louis M Charbonnier; Amir H Massoud; Carmen Leon-Astudillo; Gary Visner; Meera Subramaniam; Wanda Phipatanakul; Talal A Chatila
Journal:  J Allergy Clin Immunol Pract       Date:  2019-03-15

Review 7.  Early life factors that affect allergy development.

Authors:  Lisa A Reynolds; B Brett Finlay
Journal:  Nat Rev Immunol       Date:  2017-05-15       Impact factor: 53.106

8.  Jagged1-expressing adenovirus-infected dendritic cells induce expansion of Foxp3+ regulatory T cells and alleviate T helper type 2-mediated allergic asthma in mice.

Authors:  Chu-Lun Lin; Huei-Mei Huang; Chia-Ling Hsieh; Chia-Kwung Fan; Yueh-Lun Lee
Journal:  Immunology       Date:  2018-11-29       Impact factor: 7.397

9.  Osthole treatment ameliorates Th2-mediated allergic asthma and exerts immunomodulatory effects on dendritic cell maturation and function.

Authors:  Chen-Yuan Chiang; Chen-Chen Lee; Chia-Kwung Fan; Huei-Mei Huang; Bor-Luen Chiang; Yueh-Lun Lee
Journal:  Cell Mol Immunol       Date:  2017-08-07       Impact factor: 11.530

10.  Prostaglandin I2 signaling licenses Treg suppressive function and prevents pathogenic reprogramming.

Authors:  Allison E Norlander; Melissa H Bloodworth; Shinji Toki; Jian Zhang; Weisong Zhou; Kelli Boyd; Vasiliy V Polosukhin; Jacqueline-Yvonne Cephus; Zachary J Ceneviva; Vivek D Gandhi; Nowrin U Chowdhury; Louis-Marie Charbonnier; Lisa M Rogers; Janey Wang; David M Aronoff; Lisa Bastarache; Dawn C Newcomb; Talal A Chatila; R Stokes Peebles
Journal:  J Clin Invest       Date:  2021-04-01       Impact factor: 14.808
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