Literature DB >> 27595457

Polygenic score prediction captures nearly all common genetic risk for Alzheimer's disease.

Valentina Escott-Price1, Maryam Shoai2, Richard Pither3, Julie Williams4, John Hardy5.   

Abstract

We estimate the maximum prediction accuracy for the risk of Alzheimer's disease based on disease prevalence and heritability of liability. We demonstrate that the recently reported AUC values for predicting of Alzheimer's disease using polygenic scores reach about 90% of the estimated maximum accuracy that can be achieved by predictors of genetic risk based on genomic profiles.
Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  AUC; Heritability; Polygenic score

Mesh：

Year:  2016        PMID： 27595457     DOI： 10.1016/j.neurobiolaging.2016.07.018

Source DB:  PubMed          Journal:  Neurobiol Aging        ISSN： 0197-4580            Impact factor:   4.673


  59 in total

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Authors:  Yuetiva Deming; Zeran Li; Bruno A Benitez; Carlos Cruchaga
Journal:  Expert Opin Ther Targets       Date:  2018-06-20       Impact factor: 6.902

2.  Integration of genetic and clinical information to improve imputation of data missing from electronic health records.

Authors:  Ruowang Li; Yong Chen; Jason H Moore
Journal:  J Am Med Inform Assoc       Date:  2019-10-01       Impact factor: 4.497

3.  Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers.

Authors:  Yuetiva Deming; Zeran Li; Manav Kapoor; Oscar Harari; Jorge L Del-Aguila; Kathleen Black; David Carrell; Yefei Cai; Maria Victoria Fernandez; John Budde; Shengmei Ma; Benjamin Saef; Bill Howells; Kuan-Lin Huang; Sarah Bertelsen; Anne M Fagan; David M Holtzman; John C Morris; Sungeun Kim; Andrew J Saykin; Philip L De Jager; Marilyn Albert; Abhay Moghekar; Richard O'Brien; Matthias Riemenschneider; Ronald C Petersen; Kaj Blennow; Henrik Zetterberg; Lennart Minthon; Vivianna M Van Deerlin; Virginia Man-Yee Lee; Leslie M Shaw; John Q Trojanowski; Gerard Schellenberg; Jonathan L Haines; Richard Mayeux; Margaret A Pericak-Vance; Lindsay A Farrer; Elaine R Peskind; Ge Li; Antonio F Di Narzo; John S K Kauwe; Alison M Goate; Carlos Cruchaga
Journal:  Acta Neuropathol       Date:  2017-02-28       Impact factor: 17.088

4.  PRECISION MEDICINE - The Golden Gate for Detection, Treatment and Prevention of Alzheimer's Disease.

Authors:  H Hampel; S E O'Bryant; J I Castrillo; C Ritchie; K Rojkova; K Broich; N Benda; R Nisticò; R A Frank; B Dubois; V Escott-Price; S Lista
Journal:  J Prev Alzheimers Dis       Date:  2016-09-06

5.  Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms.

Authors:  Carlos Cruchaga; Jorge L Del-Aguila; Benjamin Saef; Kathleen Black; Maria Victoria Fernandez; John Budde; Laura Ibanez; Yuetiva Deming; Manav Kapoor; Giuseppe Tosto; Richard P Mayeux; David M Holtzman; Anne M Fagan; John C Morris; Randall J Bateman; Alison M Goate; Oscar Harari
Journal:  Alzheimers Dement       Date:  2017-09-21       Impact factor: 21.566

Review 6.  Genetics of Alzheimer's Disease: the Importance of Polygenic and Epistatic Components.

Authors:  Neha Raghavan; Giuseppe Tosto
Journal:  Curr Neurol Neurosci Rep       Date:  2017-08-21       Impact factor: 5.081

Review 7.  A multiomics approach to heterogeneity in Alzheimer's disease: focused review and roadmap.

Authors:  AmanPreet Badhwar; G Peggy McFall; Shraddha Sapkota; Sandra E Black; Howard Chertkow; Simon Duchesne; Mario Masellis; Liang Li; Roger A Dixon; Pierre Bellec
Journal:  Brain       Date:  2020-05-01       Impact factor: 13.501

Review 8.  Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology.

Authors:  Harald Hampel; Nicola Toschi; Claudio Babiloni; Filippo Baldacci; Keith L Black; Arun L W Bokde; René S Bun; Francesco Cacciola; Enrica Cavedo; Patrizia A Chiesa; Olivier Colliot; Cristina-Maria Coman; Bruno Dubois; Andrea Duggento; Stanley Durrleman; Maria-Teresa Ferretti; Nathalie George; Remy Genthon; Marie-Odile Habert; Karl Herholz; Yosef Koronyo; Maya Koronyo-Hamaoui; Foudil Lamari; Todd Langevin; Stéphane Lehéricy; Jean Lorenceau; Christian Neri; Robert Nisticò; Francis Nyasse-Messene; Craig Ritchie; Simone Rossi; Emiliano Santarnecchi; Olaf Sporns; Steven R Verdooner; Andrea Vergallo; Nicolas Villain; Erfan Younesi; Francesco Garaci; Simone Lista
Journal:  J Alzheimers Dis       Date:  2018       Impact factor: 4.472

9.  Polygenic risk score analysis of pathologically confirmed Alzheimer disease.

Authors:  Valentina Escott-Price; Amanda J Myers; Matt Huentelman; John Hardy
Journal:  Ann Neurol       Date:  2017-08-09       Impact factor: 10.422

10.  Assessment of the Genetic Architecture of Alzheimer's Disease Risk in Rate of Memory Decline.

Authors:  Jorge L Del-Aguila; Maria Victoria Fernández; Suzanne Schindler; Laura Ibanez; Yuetiva Deming; Shengmei Ma; Ben Saef; Kathleen Black; John Budde; Joanne Norton; Rachel Chasse; Oscar Harari; Alison Goate; Chengjie Xiong; John C Morris; Carlos Cruchaga
Journal:  J Alzheimers Dis       Date:  2018       Impact factor: 4.472
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