Salim Bary Barywani1, Max Petzold2. 1. a Department of Molecular and Clinical Medicine , Sahlgrenska Academy, Sahlgrenska University Hospital (SU)/Östra Hospital, University of Gothenburg , Gothenburg , Sweden. 2. b Department of Biostatistic , University of Gothenburg , Gothenburg , Sweden.
Abstract
OBJECTIVE: A substantial part of deaths and readmissions in octogenarians with acute coronary syndrome (ACS) is assumed to be of non-cardiovascular causes. However, limited data on cause-specific long-term mortality and hospital readmissions are available. This study was aimed to investigate 5-year cause-specific deaths and re-hospitalizations as well as their prognostic predictors among octogenarians with ACS managed with percutaneous coronary intervention (PCI). METHODS: A total of 181 octogenarians managed with PCI on ACS indication during 2006-2007 at Sahlgrenska University Hospital were included. The time-period was chosen to allow a follow-up period of five years. RESULTS: All-cause 5-year mortality was 46%. Approximately 70% of deaths were cardiovascular. All-cause hospital readmissions were 71%. The majority of readmissions were due to non-cardiovascular diseases, 61% of all readmissions. Cox proportional-hazard regression analyses for cardiovascular mortality identified female sex and culprit lesion in left coronary arteries as independent predictors. Negative binomial regression models showed female sex and complications during index hospitalization as independent predictors of increased cardiovascular re-hospitalizations and prior smoking as independent predictor of increased non-cardiovascular re-hospitalizations. CONCLUSIONS: In an octogenarian cohort presented with ACS treated with PCI, cardiovascular diseases were the main causes of deaths, whereas non-cardiovascular diseases were the main causes of re-hospitalizations.
OBJECTIVE: A substantial part of deaths and readmissions in octogenarians with acute coronary syndrome (ACS) is assumed to be of non-cardiovascular causes. However, limited data on cause-specific long-term mortality and hospital readmissions are available. This study was aimed to investigate 5-year cause-specific deaths and re-hospitalizations as well as their prognostic predictors among octogenarians with ACS managed with percutaneous coronary intervention (PCI). METHODS: A total of 181 octogenarians managed with PCI on ACS indication during 2006-2007 at Sahlgrenska University Hospital were included. The time-period was chosen to allow a follow-up period of five years. RESULTS: All-cause 5-year mortality was 46%. Approximately 70% of deaths were cardiovascular. All-cause hospital readmissions were 71%. The majority of readmissions were due to non-cardiovascular diseases, 61% of all readmissions. Cox proportional-hazard regression analyses for cardiovascular mortality identified female sex and culprit lesion in left coronary arteries as independent predictors. Negative binomial regression models showed female sex and complications during index hospitalization as independent predictors of increased cardiovascular re-hospitalizations and prior smoking as independent predictor of increased non-cardiovascular re-hospitalizations. CONCLUSIONS: In an octogenarian cohort presented with ACS treated with PCI, cardiovascular diseases were the main causes of deaths, whereas non-cardiovascular diseases were the main causes of re-hospitalizations.
Authors: Heli M Lahtela; Aissa Bah; Tuomas Kiviniemi; Wail Nammas; Axel Schlitt; Andrea Rubboli; Pasi P Karjalainen; Marco Proietti; Juha E K Hartikainen; Gregory Y H Lip; K E Juhani Airaksinen Journal: Clin Cardiol Date: 2017-12-15 Impact factor: 2.882
Authors: Kirstine N Hansen; Manijeh Noori; Evald H Christiansen; Eskild B Kristiansen; Michael Maeng; Ann Dorthe O Zwisler; Britt Borregaard; Rikke Søgaard; Karsten T Veien; Anders Junker; Lisette Okkels Jensen Journal: Diab Vasc Dis Res Date: 2022 Jul-Aug Impact factor: 3.541