Literature DB >> 27595053

HDAC6 is a Regulator of CTL Function through Control of Lytic Granule Dynamics.

Francisco Sanchez-Madrid1,2, Noa Beatriz Martin-Cofreces1,2, Norman Nunez-Andrade1,2.   

Abstract

Viral infections involve specific stress exposure that can influence the quality and average lifespan of an organism. The immune system acts through virus clearance from the organism. Many aspects of immune cells accounting for this response are still under study. Here, we review recent aspects of the molecular mechanisms involved in the delivery of the lethal hit by Cytotoxic T lymphocytes.

Entities:  

Keywords:  Centrosome; HDAC6; Kinesin; Lytic granule; Microtubule

Year:  2016        PMID： 27595053      PMCID： PMC5010127          DOI： 10.4172/2168-9431.1000143

Source DB:  PubMed          Journal:  Single Cell Biol


  30 in total

1.  HDAC6 is a microtubule-associated deacetylase.

Authors:  Charlotte Hubbert; Amaris Guardiola; Rong Shao; Yoshiharu Kawaguchi; Akihiro Ito; Andrew Nixon; Minoru Yoshida; Xiao-Fan Wang; Tso-Pang Yao
Journal:  Nature       Date:  2002-05-23       Impact factor: 49.962

Review 2.  Signal transduction by T-cell receptors: mobilization of Ca and regulation of Ca-dependent effector molecules.

Authors:  B A Premack; P Gardner
Journal:  Am J Physiol       Date:  1992-12

3.  HDAC6 deacetylase activity links the tubulin cytoskeleton with immune synapse organization.

Authors:  Juan M Serrador; Jose Román Cabrero; David Sancho; María Mittelbrunn; Ana Urzainqui; Francisco Sánchez-Madrid
Journal:  Immunity       Date:  2004-04       Impact factor: 31.745

Review 4.  Lytic granules, secretory lysosomes and disease.

Authors:  Richard Clark; Gillian M Griffiths
Journal:  Curr Opin Immunol       Date:  2003-10       Impact factor: 7.486

5.  Centrosome polarization delivers secretory granules to the immunological synapse.

Authors:  Jane C Stinchcombe; Endre Majorovits; Giovanna Bossi; Stephen Fuller; Gillian M Griffiths
Journal:  Nature       Date:  2006-09-28       Impact factor: 49.962

6.  Characterization of the two catalytic domains in histone deacetylase 6.

Authors:  Hua Zou; Yiqin Wu; Marc Navre; Bi-Ching Sang
Journal:  Biochem Biophys Res Commun       Date:  2006-01-06       Impact factor: 3.575

7.  Regulation of the Src family kinase Lck by Hsp90 and ubiquitination.

Authors:  Ana Giannini; Marie-José Bijlmakers
Journal:  Mol Cell Biol       Date:  2004-07       Impact factor: 4.272

8.  Deacetylase inhibition promotes the generation and function of regulatory T cells.

Authors:  Ran Tao; Edwin F de Zoeten; Engin Ozkaynak; Chunxia Chen; Liqing Wang; Paige M Porrett; Bin Li; Laurence A Turka; Eric N Olson; Mark I Greene; Andrew D Wells; Wayne W Hancock
Journal:  Nat Med       Date:  2007-10-07       Impact factor: 53.440

Review 9.  Secretory mechanisms in cell-mediated cytotoxicity.

Authors:  Jane C Stinchcombe; Gillian M Griffiths
Journal:  Annu Rev Cell Dev Biol       Date:  2007       Impact factor: 13.827

10.  Rab27a is required for regulated secretion in cytotoxic T lymphocytes.

Authors:  J C Stinchcombe; D C Barral; E H Mules; S Booth; A N Hume; L M Machesky; M C Seabra; G M Griffiths
Journal:  J Cell Biol       Date:  2001-02-19       Impact factor: 10.539
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