Literature DB >> 27594537

Endothelial cell metabolism: A novel player in atherosclerosis? Basic principles and therapeutic opportunities.

Andreas Pircher1, Lucas Treps1, Natalia Bodrug2, Peter Carmeliet3.   

Abstract

Atherosclerosis is a leading cause of morbidity and mortality in Western society. Despite improved insight into disease pathogenesis and therapeutic options, additional treatment strategies are required. Emerging evidence highlights the relevance of endothelial cell (EC) metabolism for angiogenesis, and indicates that EC metabolism is perturbed when ECs become dysfunctional to promote atherogenesis. In this review, we overview the latest insights on EC metabolism and discuss current knowledge on how atherosclerosis deregulates EC metabolism, and how maladaptation of deregulated EC metabolism can contribute to atherosclerosis progression. We will also highlight possible therapeutic avenues, based on targeting EC metabolism.
Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Angiogenesis; Atherosclerosis; Endothelial cell; Endothelial cell metabolism; Glycolysis

Mesh：

Substances：

Year:  2016        PMID： 27594537     DOI： 10.1016/j.atherosclerosis.2016.08.011

Source DB:  PubMed          Journal:  Atherosclerosis        ISSN： 0021-9150            Impact factor:   5.162


  29 in total

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5.  Altered cargo proteins of human plasma endothelial cell-derived exosomes in atherosclerotic cerebrovascular disease.

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7.  Immunometabolic Endothelial Phenotypes: Integrating Inflammation and Glucose Metabolism.

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Review 9.  Microvesicles in Atherosclerosis and Angiogenesis: From Bench to Bedside and Reverse.

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Review 10.  From Mitochondria to Atherosclerosis: The Inflammation Path.

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Journal:  Biomedicines       Date:  2021-03-05
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