AIM: Accumulation level of fluorescent advanced glycation end products (AGEs) in the skin can be measured non-invasively as skin autofluorescence (skin AF) by autofluorescence reader. The aim of this study was to assess possible associations between skin AF and diabetic complications, especially early-stage atherosclerosis, in Japanese type 1 diabetic patients. METHODS: Skin AF was measured by AGE reader® in 105 Japanese type 1 diabetic patients (34 men and 71 women, aged 37.4±12.4 years (±SD)) and 23 age-matched healthy non-diabetic subjects. Ultrasonic carotid intima-media thickness (IMT), ankle-brachial index (ABI), and brachial ankle pulse wave velocity (baPWV) were evaluated as indices of early-stage diabetic macroangiopathy. Urinary albumin-to-creatinine ratio (UACR), the coefficient of variation of R-R intervals (CVR-R), and presence of retinopathy were also evaluated. RESULTS: Skin AF values were significantly higher in type 1 diabetic patients than in healthy controls (2.07±0.50 (mean±SD) and 1.90±0.26, respectively, p=0.024). Skin AF was associated with carotid IMT (r=0.446, p＜0.001) and baPWV (r=0.450, p＜0.001), but not with ABI (r=－0.019, p=0.8488). Notably, skin AF was an independent risk factor for IMT thickening. Similarly, skin AF was associated with log (UACR) (r=0.194, p=0.049) and was an independent risk factor for UACR. Furthermore, skin AF values were significantly higher in patients with diabetic retinopathy than in those without (2.21±0.08 and 1.97±0.06, respectively, p=0.020). CONCLUSIONS: Skin AF was significantly associated with the presence and/or severity of diabetic complications and was an independent risk factor for carotid atherosclerosis.
AIM: Accumulation level of fluorescent advanced glycation end products (AGEs) in the skin can be measured non-invasively as skin autofluorescence (skin AF) by autofluorescence reader. The aim of this study was to assess possible associations between skin AF and diabetic complications, especially early-stage atherosclerosis, in Japanese type 1 diabeticpatients. METHODS:Skin AF was measured by AGE reader® in 105 Japanese type 1 diabeticpatients (34 men and 71 women, aged 37.4±12.4 years (±SD)) and 23 age-matched healthy non-diabetic subjects. Ultrasonic carotid intima-media thickness (IMT), ankle-brachial index (ABI), and brachial ankle pulse wave velocity (baPWV) were evaluated as indices of early-stage diabetic macroangiopathy. Urinary albumin-to-creatinine ratio (UACR), the coefficient of variation of R-R intervals (CVR-R), and presence of retinopathy were also evaluated. RESULTS:Skin AF values were significantly higher in type 1 diabeticpatients than in healthy controls (2.07±0.50 (mean±SD) and 1.90±0.26, respectively, p=0.024). Skin AF was associated with carotid IMT (r=0.446, p＜0.001) and baPWV (r=0.450, p＜0.001), but not with ABI (r=－0.019, p=0.8488). Notably, skin AF was an independent risk factor for IMT thickening. Similarly, skin AF was associated with log (UACR) (r=0.194, p=0.049) and was an independent risk factor for UACR. Furthermore, skin AF values were significantly higher in patients with diabetic retinopathy than in those without (2.21±0.08 and 1.97±0.06, respectively, p=0.020). CONCLUSIONS:Skin AF was significantly associated with the presence and/or severity of diabetic complications and was an independent risk factor for carotid atherosclerosis.
Authors: S S Soedamah-Muthu; J H Fuller; H E Mulnier; V S Raleigh; R A Lawrenson; H M Colhoun Journal: Diabetologia Date: 2006-01-24 Impact factor: 10.122
Authors: H Tsuji; N Iehara; T Masegi; M Imura; J Ohkawa; H Arai; K Ishii; T Kita; T Doi Journal: Biochem Biophys Res Commun Date: 1998-04-17 Impact factor: 3.575
Authors: C Cerami; H Founds; I Nicholl; T Mitsuhashi; D Giordano; S Vanpatten; A Lee; Y Al-Abed; H Vlassara; R Bucala; A Cerami Journal: Proc Natl Acad Sci U S A Date: 1997-12-09 Impact factor: 11.205
Authors: A M Schmidt; O Hori; J X Chen; J F Li; J Crandall; J Zhang; R Cao; S D Yan; J Brett; D Stern Journal: J Clin Invest Date: 1995-09 Impact factor: 14.808
Authors: Trevor J Orchard; Timothy J Lyons; Patricia A Cleary; Barbara H Braffett; John Maynard; Catherine Cowie; Rose A Gubitosi-Klug; Jeff Way; Karen Anderson; Annette Barnie; Stephan Villavicencio Journal: Diabetes Care Date: 2013-06-28 Impact factor: 19.112
Authors: Martijn A M den Dekker; Marjan Zwiers; Edwin R van den Heuvel; Lisanne C de Vos; Andries J Smit; Clark J Zeebregts; Matthijs Oudkerk; Rozemarijn Vliegenthart; Joop D Lefrandt; Douwe J Mulder Journal: PLoS One Date: 2013-12-23 Impact factor: 3.240
Authors: Erin L Tomaszewski; Trevor J Orchard; Marquis Hawkins; Baqiyyah N Conway; Jeanine M Buchanich; John Maynard; Thomas Songer; Tina Costacou Journal: J Diabetes Complications Date: 2020-10-23 Impact factor: 2.852
Authors: Erin L Tomaszewski; Trevor J Orchard; Marquis S Hawkins; Rebecca B N Conway; Jeanine M Buchanich; John Maynard; Thomas Songer; Tina Costacou Journal: J Diabetes Sci Technol Date: 2021-05-15
Authors: Anastasia Poznyak; Andrey V Grechko; Paolo Poggio; Veronika A Myasoedova; Valentina Alfieri; Alexander N Orekhov Journal: Int J Mol Sci Date: 2020-03-06 Impact factor: 5.923