Bedia Gulen1, Cenker Eken2, Okkes Taha Kucukdagli3, Mustafa Serinken4, Abdurrahim Kocyigit5, Elif Kılıc6, Hüseyin Uyarel7. 1. Bezmialem Vakif University, Department of Emergency Medicine, Istanbul, Turkey. Electronic address: drbediagulen@yahoo.com. 2. Akdeniz University, Department of EmergencyMedicine, Antalya, Turkey. Electronic address: cenkereken@akdeniz.edu.tr. 3. Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey. Electronic address: drotaha@gmail.com. 4. Pamukkale University, Department of Emergency Medicine, Denizli, Turkey. Electronic address: mserinken@hotmail.com. 5. Bezmialem Vakif University, Department of Biochemistry, Istanbul, Turkey. Electronic address: abdurrahimkocyigit@yahoo.com. 6. Bezmialem Vakif University, Department of Biochemistry, Istanbul, Turkey. Electronic address: drekilic@gmail.com. 7. Bezmialem Vakif University, Department of Cardiology, Istanbul, Turkey.
Abstract
BACKGROUND: High blood pressure is still a challenge for emergency physicians to discern the patients that require further analysis to establish the existence of acute hypertensive target organ damage (TOD). The present study aimed to reveal that adropin levels are useful for detecting TOD in patients presenting with high blood pressure. METHODS: Patients presenting with a blood pressure of more than 180/110 mm Hg were enrolled into the study. After a resting period of 15 minutes, patients' blood pressures were measured thrice at 5-minute intervals while the patients were sitting on a chair, and the average of these measurements was accepted as the baseline value. Blood samples were obtained for either adropin levels or possible TOD during the emergency department admission. RESULTS: A total of 119 patients were included in the study. The mean systolic and diastolic blood pressures of study patients were 204.8±23.2 and 108.3 ± 10.3, respectively, and 42% (n = 50) of the patients had TOD. Although the adropin levels were similar between the patients with or without TOD (TOD group = 195 pg/mL, interquartile range [IQR]: 178-201; no-TOD group = 196 pg/mL, IQR: 176-204 [P = .982]), it is significantly higher in normotensive patients (normotensive group = 289 pg/mL, IQR: 193-403) compared with the hypertensive ones (P < .001). CONCLUSIONS: Despite the significantly higher levels of adropin in normotensive patients compared with hypertensive ones, adropin could not be used as a decision tool for detecting TOD in patients presenting with high blood pressure to the emergency department.
BACKGROUND: High blood pressure is still a challenge for emergency physicians to discern the patients that require further analysis to establish the existence of acute hypertensive target organ damage (TOD). The present study aimed to reveal that adropin levels are useful for detecting TOD in patients presenting with high blood pressure. METHODS:Patients presenting with a blood pressure of more than 180/110 mm Hg were enrolled into the study. After a resting period of 15 minutes, patients' blood pressures were measured thrice at 5-minute intervals while the patients were sitting on a chair, and the average of these measurements was accepted as the baseline value. Blood samples were obtained for either adropin levels or possible TOD during the emergency department admission. RESULTS: A total of 119 patients were included in the study. The mean systolic and diastolic blood pressures of study patients were 204.8±23.2 and 108.3 ± 10.3, respectively, and 42% (n = 50) of the patients had TOD. Although the adropin levels were similar between the patients with or without TOD (TOD group = 195 pg/mL, interquartile range [IQR]: 178-201; no-TOD group = 196 pg/mL, IQR: 176-204 [P = .982]), it is significantly higher in normotensive patients (normotensive group = 289 pg/mL, IQR: 193-403) compared with the hypertensive ones (P < .001). CONCLUSIONS: Despite the significantly higher levels of adropin in normotensive patients compared with hypertensive ones, adropin could not be used as a decision tool for detecting TOD in patients presenting with high blood pressure to the emergency department.
Authors: Mariami Jasaszwili; Maria Billert; Mathias Z Strowski; Krzysztof W Nowak; Marek Skrzypski Journal: Molecules Date: 2020-01-27 Impact factor: 4.411