Literature DB >> 2759243

Linker histone-DNA complexes: enhanced stability in the presence of aluminum lactate and implications for Alzheimer's disease.

W J Lukiw1, T P Kruck, D R McLachlan.   

Abstract

The binding of human brain linker histone proteins to a radiolabelled human Alu repetitive element was examined by mobility shift assay. Analysis of the complexes formed from protein extracts of whole neocortical nuclei, under physiological conditions in vitro revealed that linker histone H1(0) has the highest affinity for the Alu DNA sequence. The linker histone-DNA complexes assembled in the presence of aluminum lactate were more resistant to sodium chloride-induced dissociation than those formed in the presence of sodium lactate. The enhanced stability of deoxyribonucleoprotein (DNP) complexes in the presence of the aluminum cation may be of significance in neurodegenerative conditions such as Alzheimer's disease where aluminum preferentially associates with DNA containing structures of the nucleus.

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Year:  1989        PMID： 2759243     DOI： 10.1016/0014-5793(89)80929-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

Review 1.  The molecular mechanisms of scrapie encephalopathy and relevance to human neurodegenerative disease.

Authors:  W J Lukiw; H J Cho; J C Kaufmann; D R Crapper McLachlan
Journal:  Can J Vet Res       Date:  1990-01       Impact factor: 1.310

2.  Budesonide epimer R or dexamethasone selectively inhibit platelet-activating factor-induced or interleukin 1beta-induced DNA binding activity of cis-acting transcription factors and cyclooxygenase-2 gene expression in human epidermal keratinocytes.

Authors:  W J Lukiw; R P Pelaez; J Martinez; N G Bazan
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-31       Impact factor: 11.205

3.  Run-on gene transcription in human neocortical nuclei. Inhibition by nanomolar aluminum and implications for neurodegenerative disease.

Authors:  W J Lukiw; H J LeBlanc; L A Carver; D R McLachlan; N G Bazan
Journal:  J Mol Neurosci       Date:  1998-08       Impact factor: 3.444

4.  Aluminum in Neurological and Neurodegenerative Disease.

Authors:  Donald R C McLachlan; Catherine Bergeron; Peter N Alexandrov; William J Walsh; Aileen I Pogue; Maire E Percy; Theodore P A Kruck; Zhide Fang; Nathan M Sharfman; Vivian Jaber; Yuhai Zhao; Wenhong Li; Walter J Lukiw
Journal:  Mol Neurobiol       Date:  2019-01-31       Impact factor: 5.590

5.  Aluminum in neurological disease - a 36 year multicenter study.

Authors:  Walter J Lukiw; Theodore P A Kruck; Maire E Percy; Aileen I Pogue; Peter N Alexandrov; William J Walsh; Nathan M Sharfman; Vivian R Jaber; Yuhai Zhao; Wenhong Li; Catherine Bergeron; Frank Culicchia; Zhide Fang; Donald R C McLachlan
Journal:  J Alzheimers Dis Parkinsonism       Date:  2018-11-29

6.  Metal-sulfate induced generation of ROS in human brain cells: detection using an isomeric mixture of 5- and 6-carboxy-2',7'-dichlorofluorescein diacetate (carboxy-DCFDA) as a cell permeant tracer.

Authors:  Aileen I Pogue; Brandon M Jones; Surjyadipta Bhattacharjee; Maire E Percy; Yuhai Zhao; Walter J Lukiw
Journal:  Int J Mol Sci       Date:  2012-08-02       Impact factor: 6.208
  6 in total

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