| Literature DB >> 27592134 |
Yuanying Fang1, Zunhua Yang2, Hui Ouyang1, Rikang Wang1, Jun Li1, Hesong Huang1, Yi Jin1, Yulin Feng1, Shilin Yang2.
Abstract
Modification of Hederacolchiside A1 (HA1) on 28-COOH gave a series of novel triterpenoid saponin compounds containing ester or amide group. Comparing with natural product HA1, several derivatives showed decreased toxicity in the mice acute toxicity trial and increased the anticancer activity in vitro. Especially compound 1 exhibited the strongest antiproliferative activities against human cancer cell lines tested (IC50=1.1-4.6μM) and potent tumor inhibition rate in vivo (46.8%).Entities:
Keywords: Anticancer activity; Derivatives; Hederacolchiside A(1); Triterpenoid saponins
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Year: 2016 PMID： 27592134 DOI： 10.1016/j.bmcl.2016.08.077
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823