Literature DB >> 2759202

Antiproliferative effects of 4',5'-unsaturated adenine nucleosides on leukemia L1210 cells in vitro.

B Sheid1, L M Lerner, E Gaetjens.   

Abstract

Several 4',5'-unsaturated adenine nucleosides were shown to have antiproliferative activity against L1210 leukemia cells in vitro. The active nucleosides were cytotoxic to the L1210 cells as demonstrated by Trypan Blue uptake. The cytotoxicity was not induced by alterations in the ribonucleoside and deoxyribonucleoside triphosphate levels of the L1210 cells.

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Year:  1989        PMID： 2759202     DOI： 10.1007/BF01974570

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  11 in total

1.  Synthesis of 9-(2,5-dideoxy-beta-D-glycero-pent-4-enofuranosyl)adenine.

Authors:  N Suciu; L M Lerner
Journal:  Carbohydr Res       Date:  1975-10       Impact factor: 2.104

2.  2,6-Diaminopurinedeoxyriboside as a prodrug of deoxyguanosine in L1210 cells.

Authors:  G Weckbecker; J G Cory
Journal:  Cancer Res       Date:  1987-05-01       Impact factor: 12.701

3.  An analytical system for rapid separation of tissue nucleotides at low pressures on conventional anion exchangers.

Authors:  J X Khym
Journal:  Clin Chem       Date:  1975-08       Impact factor: 8.327

4.  Enantiomeric forms of 9-(5-deoxy-beta-erythro-pent-4-enofuranosyl)adenine and a new preparation of 5-deoxy-D-lyxose.

Authors:  L M Lerner
Journal:  Carbohydr Res       Date:  1977-02       Impact factor: 2.104

Review 5.  Inherited biochemical defects in lymphocytes causing immunodeficiency disease.

Authors:  E R Giblett
Journal:  Prog Clin Biol Res       Date:  1981

Review 6.  Toxicity of naturally occurring purine deoxyribonucleosides.

Authors:  J F Henderson; F W Scott; J K Lowe
Journal:  Pharmacol Ther       Date:  1980       Impact factor: 12.310

7.  Comparison of sample preparation methods for the high-performance liquid chromatographic analysis of cell culture extracts for triphosphate ribonucleosides and deoxyribonucleosides.

Authors:  J Harmenberg; A H Karlsson; G Gilljam
Journal:  Anal Biochem       Date:  1987-02-15       Impact factor: 3.365

8.  Preparation of the enantiomeric forms of 9-(5-deoxy-alpha-threo-pent-4-enofuranosyl)adenine and 9-(3,5-dideoxy-beta-D-glycero-pent-4-enofuranosyl)adenine and in vitro antileukemic screening.

Authors:  V K Srivastava; L M Lerner
Journal:  J Med Chem       Date:  1979-01       Impact factor: 7.446

9.  Preparation and antileukemic screening of some new 6'-deoxyhexopyranosyladenine nucleosides.

Authors:  L M Lerner; B Sheid; E Gaetjens
Journal:  J Med Chem       Date:  1987-08       Impact factor: 7.446

10.  Determination of ribonucleoside triphosphates and deoxyribonucleoside triphosphates in Novikoff hepatoma cells by high-performance liquid chromatography.

Authors:  F Arezzo
Journal:  Anal Biochem       Date:  1987-01       Impact factor: 3.365
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  1 in total

1.  Antiproliferative activity of purine nucleoside dialdehydes against leukemia L1210 in vitro.

Authors:  B Sheid; M Saggar; E Gaetjens; L M Lerner
Journal:  Cancer Chemother Pharmacol       Date:  1991       Impact factor: 3.333
  1 in total

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