Literature DB >> 2759201

gamma-Aminobutyric acid uptake by rat kidney brush-border membrane vesicles.

H S Sidhu1, J D Wood.   

Abstract

Brush-border membrane vesicles (BBMV) from rat kidney cortex possessed two uptake systems for gamma-aminobutyric acid (GABA), a high affinity system (Km = 10.9 microM) and a low affinity system (Km = 1203 microM). Both uptake systems were inhibited by p-hydroxymercuribenzoic acid and ouabain, and by the action of neuraminidase, whereas the GABA analogs nipecotic acid, beta-alanine, 2,4-diaminobutyric acid and 4,5,6,7-tetrahydroisoxazolo-[4,5 c]-pyridin-3-ol had no effect on the GABA uptake activity. The BBMV uptake systems were clearly different from the GABA transport systems present in brain tissue.

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Year:  1989        PMID： 2759201     DOI： 10.1007/BF01974569

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  8 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  Role of sialic acid in synaptosomal transport of amino acid transmitters.

Authors:  M M Zaleska; M Erecińska
Journal:  Proc Natl Acad Sci U S A       Date:  1987-03       Impact factor: 11.205

3.  Determination of protein: a modification of the Lowry method that gives a linear photometric response.

Authors:  E F Hartree
Journal:  Anal Biochem       Date:  1972-08       Impact factor: 3.365

4.  Detectability of high and low affinity uptake systems for GABA and glutamate in rat brain slices and synaptosomes.

Authors:  G Levi; M Raiteri
Journal:  Life Sci I       Date:  1973-01-15

5.  Ligand: a versatile computerized approach for characterization of ligand-binding systems.

Authors:  P J Munson; D Rodbard
Journal:  Anal Biochem       Date:  1980-09-01       Impact factor: 3.365

6.  A comparative study and partial characterization of multi-uptake systems for gamma-aminobutyric acid.

Authors:  J D Wood; H S Sidhu
Journal:  J Neurochem       Date:  1987-10       Impact factor: 5.372

7.  A gamma-aminobutyric acid-specific transport mechanism in mammalian kidney.

Authors:  P R Goodyer; R Rozen; C R Scriver
Journal:  Biochim Biophys Acta       Date:  1985-08-08

8.  Uptake of gamma-aminobutyric acid by brain tissue preparations: a reevaluation.

Authors:  J D Wood; H S Sidhu
Journal:  J Neurochem       Date:  1986-03       Impact factor: 5.372
  8 in total
  2 in total

1.  Releasable GABA in tubular epithelium of rat kidney.

Authors:  S L Erdö; E Dobó; A Párducz; J R Wolff
Journal:  Experientia       Date:  1991-03-15

2.  Comparison of GABA uptake by brain and kidney preparations.

Authors:  J D Wood; H S Sidhu
Journal:  Amino Acids       Date:  1991-02       Impact factor: 3.520
  2 in total

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