Literature DB >> 27591999

Knockout of arsenic (+3 oxidation state) methyltransferase results in sex-dependent changes in phosphatidylcholine metabolism in mice.

Madelyn C Huang1, Christelle C Douillet2, Miroslav Stýblo3,4.   

Abstract

Arsenic (+3 oxidation state) methyltransferase is the key enzyme in the methylation pathway for inorganic arsenic. We have recently shown that As3mt knockout (KO) has a profound effect on metabolomic profiles in mice. Phosphatidylcholine species (PCs) were the largest group of metabolites altered in both plasma and urine. The present study used targeted analysis to investigate the KO-associated changes in PC profiles in the liver, the site of PC synthesis. Results show that As3mt KO has a systemic effect on PC metabolism and that this effect is sex dependent.

Entities:  

Keywords:  Arsenic; As3mt knockout; Liver; Mouse; Phophatidycholine; Plasma

Mesh：

Substances：

Year:  2016        PMID： 27591999      PMCID： PMC5358322          DOI： 10.1007/s00204-016-1844-2

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  13 in total

Review 1.  Arsenic (+3 oxidation state) methyltransferase and the methylation of arsenicals.

Authors:  David J Thomas; Jiaxin Li; Stephen B Waters; Weibing Xing; Blakely M Adair; Zuzana Drobna; Vicenta Devesa; Miroslav Styblo
Journal:  Exp Biol Med (Maywood)       Date:  2007-01

Review 2.  Role of phosphatidylcholine biosynthesis in the regulation of lipoprotein homeostasis.

Authors:  Dennis E Vance
Journal:  Curr Opin Lipidol       Date:  2008-06       Impact factor: 4.776

Review 3.  Mechanisms of glycerophospholipid homeostasis in mammalian cells.

Authors:  Martin Hermansson; Kati Hokynar; Pentti Somerharju
Journal:  Prog Lipid Res       Date:  2011-03-05       Impact factor: 16.195

Review 4.  Multi-dimensional mass spectrometry-based shotgun lipidomics and novel strategies for lipidomic analyses.

Authors:  Xianlin Han; Kui Yang; Richard W Gross
Journal:  Mass Spectrom Rev       Date:  2011-07-13       Impact factor: 10.946

Review 5.  Metabolism of arsenic and its toxicological relevance.

Authors:  Takayuki Watanabe; Seishiro Hirano
Journal:  Arch Toxicol       Date:  2012-07-19       Impact factor: 5.153

6.  Oxidation state specific analysis of arsenic species in tissues of wild-type and arsenic (+3 oxidation state) methyltransferase-knockout mice.

Authors:  Jenna M Currier; Christelle Douillet; Zuzana Drobná; Miroslav Stýblo
Journal:  J Environ Sci (China)       Date:  2016-07-18       Impact factor: 5.565

Review 7.  AS3MT, GSTO, and PNP polymorphisms: impact on arsenic methylation and implications for disease susceptibility.

Authors:  Ray Antonelli; Kan Shao; David J Thomas; Reeder Sams; John Cowden
Journal:  Environ Res       Date:  2014-05-08       Impact factor: 6.498

8.  Arsenic (+3 oxidation state) methyltransferase genotype affects steady-state distribution and clearance of arsenic in arsenate-treated mice.

Authors:  Michael F Hughes; Brenda C Edwards; Karen M Herbin-Davis; Jesse Saunders; Miroslav Styblo; David J Thomas
Journal:  Toxicol Appl Pharmacol       Date:  2010-09-29       Impact factor: 4.219

9.  Metabolomic profiles of arsenic (+3 oxidation state) methyltransferase knockout mice: effect of sex and arsenic exposure.

Authors:  Madelyn C Huang; Christelle Douillet; Mingming Su; Kejun Zhou; Tao Wu; Wenlian Chen; Joseph A Galanko; Zuzana Drobná; R Jesse Saunders; Elizabeth Martin; Rebecca C Fry; Wei Jia; Miroslav Stýblo
Journal:  Arch Toxicol       Date:  2016-02-16       Impact factor: 5.153

10.  Shotgun Lipidomics by Sequential Precursor Ion Fragmentation on a Hybrid Quadrupole Time-of-Flight Mass Spectrometer.

Authors:  Brigitte Simons; Dimple Kauhanen; Tuulia Sylvänne; Kirill Tarasov; Eva Duchoslav; Kim Ekroos
Journal:  Metabolites       Date:  2012-02-20
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  3 in total

1.  Targeted metabolomics to understand the association between arsenic metabolism and diabetes-related outcomes: Preliminary evidence from the Strong Heart Family Study.

Authors:  Miranda J Spratlen; Maria Grau-Perez; Jason G Umans; Joseph Yracheta; Lyle G Best; Kevin Francesconi; Walter Goessler; Teodoro Bottiglieri; Mary V Gamble; Shelley A Cole; Jinying Zhao; Ana Navas-Acien
Journal:  Environ Res       Date:  2018-09-27       Impact factor: 6.498

2.  Knockout of arsenic (+3 oxidation state) methyltransferase is associated with adverse metabolic phenotype in mice: the role of sex and arsenic exposure.

Authors:  Christelle Douillet; Madelyn C Huang; R Jesse Saunders; Ellen N Dover; Chongben Zhang; Miroslav Stýblo
Journal:  Arch Toxicol       Date:  2016-11-15       Impact factor: 5.153

3.  Arsenic 3 methyltransferase (AS3MT) automethylates on cysteine residues in vitro.

Authors:  Sofiane Y Mersaoui; Cynthia Guilbert; Hsiang Chou; Christelle Douillet; D Scott Bohle; Miroslav Stýblo; Stéphane Richard; Koren K Mann
Journal:  Arch Toxicol       Date:  2022-03-04       Impact factor: 6.168
  3 in total

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