| Literature DB >> 27591900 |
Abstract
Application of landscape theory and the dehydron hypothesis to a crystal structure of a G85R mutant superoxide dismutase (SOD1) tetrameric complex allows for the description of a prion-like hypothesis that serves to explain propagated SOD1 misfolding. We have developed two conformational-change scenarios, one local to the ESL at the complex interface, and a second displacement at the ESL of the otherdimeric subunit. When taken together these provide for a prion-like mechanism that can serve to explain the observed conversion of wtSOD1 to a misfolded form by the G85R mutant.Entities:
Keywords: Amyotrophic lateral sclerosis; Dehydrons; Electrostatic loop; Frustration contacts; G85R SOD1 mutant; Superoxide dismutase
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Year: 2016 PMID： 27591900 PMCID： PMC5030186 DOI： 10.1016/j.bbrc.2016.08.172
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575