Wesley K Lefferts1, Kevin S Heffernan2, Tiago V Barreira2. 1. Department of Exercise Science, Syracuse University, USA. Electronic address: wleffert@syr.edu. 2. Department of Exercise Science, Syracuse University, USA.
Abstract
BACKGROUND: High blood pressure (BP) may be associated with impaired cognitive function. BP is comprised of a steady (mean arterial pressure; MAP) and pulsatile (pulse pressure; PP) component. The purpose of this study was to examine the relationship between steady and pulsatile BP and cognition among adults ≥60years old. METHODS: 2058 adults age 60-85years from the 1999-2002 NHANES were used in this analysis. MAP and PP were calculated from brachial BP as 1/3 systolic +2/3 diastolic BP, and systolic - diastolic BP, respectively. Cognition was assessed using the digit-symbol substitution test (DSST). RESULTS: Unadjusted multiple regression revealed although PP independently predicted DSST score (β=-0.21, p<0.05), MAP was only predictive when entered simultaneously with PP (β=0.06, p<0.05). Further adjustments for sociodemographics and medical history significantly improved prediction of DSST score (∆R2=0.37, p<0.05), and removed the association between MAP and DSST score, although PP remained a significant predictor (β=-0.07, p<0.05). CONCLUSIONS: PP, but not MAP, was significantly and inversely related to cognitive function among a representative sample of adults aged ≥60years after controlling for sociodemographic information and medical history.
BACKGROUND: High blood pressure (BP) may be associated with impaired cognitive function. BP is comprised of a steady (mean arterial pressure; MAP) and pulsatile (pulse pressure; PP) component. The purpose of this study was to examine the relationship between steady and pulsatile BP and cognition among adults ≥60years old. METHODS: 2058 adults age 60-85years from the 1999-2002 NHANES were used in this analysis. MAP and PP were calculated from brachial BP as 1/3 systolic +2/3 diastolic BP, and systolic - diastolic BP, respectively. Cognition was assessed using the digit-symbol substitution test (DSST). RESULTS: Unadjusted multiple regression revealed although PP independently predicted DSST score (β=-0.21, p<0.05), MAP was only predictive when entered simultaneously with PP (β=0.06, p<0.05). Further adjustments for sociodemographics and medical history significantly improved prediction of DSST score (∆R2=0.37, p<0.05), and removed the association between MAP and DSST score, although PP remained a significant predictor (β=-0.07, p<0.05). CONCLUSIONS: PP, but not MAP, was significantly and inversely related to cognitive function among a representative sample of adults aged ≥60years after controlling for sociodemographic information and medical history.
Authors: Wassim Tarraf; Carlos J Rodríguez; Martha L Daviglus; Melissa Lamar; Neil Schneiderman; Linda Gallo; Gregory A Talavera; Robert C Kaplan; Myriam Fornage; Alan Conceicao; Hector M González Journal: J Alzheimers Dis Date: 2017 Impact factor: 4.472
Authors: Kathy D Wright; Maryanna D Klatt; Ingrid Richards Adams; Christopher M Nguyen; Lorraine C Mion; Alai Tan; Todd B Monroe; Karen M Rose; Douglas W Scharre Journal: J Am Geriatr Soc Date: 2020-11-23 Impact factor: 5.562