Literature DB >> 2759154

Bright white light does not improve narcoleptic symptoms.

M Hajek1, K Meier-Ewert, A Wirz-Justice, I Tobler, J Arendt, H Dick, G Fink.   

Abstract

Bright white light (500lx) for 4 h/day was applied to seven narcoleptic patients (age 47-65 years, mean 55 years). The effects of the light on the disturbed sleep-wake cycle in narcoleptics were investigated by the measurement of the following parameters: (1) excessive daytime sleepiness and sustained attention (multiple sleep latency test); (2) rest-activity cycles; (3) self-ratings (mood, anxiety, tiredness); (4) urinary cycles of 6-OH melatonin sulphate and cortisol; (5) sleep EEG. Treatment with bright light showed neither objective nor subjective changes in the clinical symptoms of narcolepsy. While similar "dosage" light applications can phase shift human circadian rhythms and improve depression and hypersomnia in winter depression, it is not an appropriate treatment for narcolepsy.

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Year:  1989        PMID: 2759154     DOI: 10.1007/BF00381466

Source DB:  PubMed          Journal:  Eur Arch Psychiatry Neurol Sci        ISSN: 0175-758X


  19 in total

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Authors:  A Wirz-Justice
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Journal:  J Clin Endocrinol Metab       Date:  1985-06       Impact factor: 5.958

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Journal:  Peptides       Date:  1980       Impact factor: 3.750

10.  Response of the melatonin cycle to phototherapy for Seasonal Affective Disorder. Short note.

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  3 in total

1.  Highly specific role of hypocretin (orexin) neurons: differential activation as a function of diurnal phase, operant reinforcement versus operant avoidance and light level.

Authors:  Ronald McGregor; Ming-Fung Wu; Grace Barber; Lalini Ramanathan; Jerome M Siegel
Journal:  J Neurosci       Date:  2011-10-26       Impact factor: 6.167

2.  Orexin (hypocretin) mediates light-dependent fluctuation of hippocampal function in a diurnal rodent.

Authors:  Joel E Soler; Hang Xiong; Faiez Samad; Fredric P Manfredsson; Alfred J Robison; Antonio A Núñez; Lily Yan
Journal:  Hippocampus       Date:  2021-07-15       Impact factor: 3.753

3.  Cerebrospinal Fluid Hypocretin-1 (Orexin-A) Level Fluctuates with Season and Correlates with Day Length.

Authors:  Kim Boddum; Mathias Hvidtfelt Hansen; Poul Jørgen Jennum; Birgitte Rahbek Kornum
Journal:  PLoS One       Date:  2016-03-23       Impact factor: 3.240

  3 in total

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