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Literature DB >> 2759123

An optimized synthesis of 18F-labelled 5-fluorouracil and a reevaluation of its use as a prognostic agent.

G W Visser¹, G C Gorree, B J Braakhuis, J D Herscheid.

Abstract

An optimized synthesis of 18F-labelled 5-fluorouracil (5-FU) is described. The biodynamics of this radiopharmaceutical were studied in nude mice bearing a 5-FU sensitive (colon 38 carcinoma) or a 5-FU resistant (R1-rhabdomyosarcoma) tumour. It was found that not the initial tumour uptake, but the efflux of the 18F activity from the tumour was correlated with the 5-FU sensitivity of the tumour.

Entities: Chemical Disease Species

Mesh：

Substances：
Fluorouracil

Year: 1989 PMID： 2759123 DOI： 10.1007/BF00257538

Source DB: PubMed Journal: Eur J Nucl Med ISSN： 0340-6997

20 in total

1. Distribution of 18F-5-fluorouracil in tumor-bearing mice and rats.

Authors: J Shani; W Wolf; T Schlesinger; H L Atkins; P R Bradley-Moore; V Casella; J S Fowler; D Greenberg; T Ido; R M Lambrecht; R MacGregor; C Mantescu; R Neirinckx; P Som; A P Wolf; I Wodinsky; K Meaney
Journal: Int J Nucl Med Biol Date: 1978-03

2. The synthesis of 18 F-5-fluorouracil. VII.

Authors: J S Fowler; R D Finn; R M Lambrecht; A P Wolf
Journal: J Nucl Med Date: 1973-01 Impact factor: 10.057

3. An improved synthesis of 18F-5-fluorouracil.

Authors: E N Vine; D Young; W H Vine; W Wolf
Journal: Int J Appl Radiat Isot Date: 1979-07

4. Experimental radiotherapy of a rat rhabdomyosarcoma with 15 MeV neutrons and 300 kV x-rays. I. Effects of single exposures.

Authors: G W Barendsen; J J Broerse
Journal: Eur J Cancer Date: 1969-09 Impact factor: 9.162

5. Enhanced accumulation of 5-fluorouracil in human tumors in athymic mice by co-administration of Ftorafur and uracil.

Authors: S G Tang; C L Hornbeck; J E Byfield
Journal: Int J Radiat Oncol Biol Phys Date: 1984-09 Impact factor: 7.038

6. Studies on 18F-labeled pyrimidines. II. Metabolic investigation of 18F-5-fluorouracil, 18F-5-fluoro-2'-deoxyuridine and 18F-5-fluorouridine in rats.

Authors: K Ishiwata; T Ido; K Kawashima; M Murakami; T Takahashi
Journal: Eur J Nucl Med Date: 1984

7. Comparative radiopharmacokinetics of 18F-5-fluorouracil administered i.v. to rats bearing a mammary tumor.

Authors: J Shani; R C Manaka; D Young; J L Cohen; W Wolf
Journal: Int J Nucl Med Biol Date: 1985

8. Studies on the mechanism of fluoropyrimidine cytotoxicity in l1210 cells: correlation with inhibition of thymidylate synthetase but not with incorporation into RNA.

Authors: K D Danenberg; D Becker; M A Mulkins; P V Danenberg
Journal: Pharm Res Date: 1984-05 Impact factor: 4.200

An optimized synthesis of 18F-labelled 5-fluorouracil and a reevaluation of its use as a prognostic agent.

1. Distribution of 18F-5-fluorouracil in tumor-bearing mice and rats.

2. The synthesis of 18 F-5-fluorouracil. VII.

3. An improved synthesis of 18F-5-fluorouracil.

4. Experimental radiotherapy of a rat rhabdomyosarcoma with 15 MeV neutrons and 300 kV x-rays. I. Effects of single exposures.

5. Enhanced accumulation of 5-fluorouracil in human tumors in athymic mice by co-administration of Ftorafur and uracil.

6. Studies on 18F-labeled pyrimidines. II. Metabolic investigation of 18F-5-fluorouracil, 18F-5-fluoro-2'-deoxyuridine and 18F-5-fluorouridine in rats.

7. Comparative radiopharmacokinetics of 18F-5-fluorouracil administered i.v. to rats bearing a mammary tumor.

8. Studies on the mechanism of fluoropyrimidine cytotoxicity in l1210 cells: correlation with inhibition of thymidylate synthetase but not with incorporation into RNA.

9. 5-fluorouracil metabolism monitored in vivo by 19F NMR.

10. Chemosensitivity of human head and neck cancer xenografts in the clonogenic assay and in nude mice.

1. Tissue distribution of [18F]-5-fluorouracil in mice: effects of route of administration, strain, tumour and dose.

Review 2. Fluorinated tracers for imaging cancer with positron emission tomography.

3. Metabolic changes of glioma following chemotherapy: an experimental study using four PET tracers.

4. Positron emission tomography (PET) imaging with (18)F-based radiotracers.

5. A Transmetalation Reaction Enables the Synthesis of [¹⁸F]5-Fluorouracil from [¹⁸F]Fluoride for Human PET Imaging.