| Literature DB >> 27591071 |
Stefania Santangeli1, Francesca Maradonna1, Ike Olivotto2, Chiara Carla Piccinetti2, Giorgia Gioacchini2, Oliana Carnevali3.
Abstract
Epigenetic modifications are classified as heritable and reversible chemical modifications of chromatin that do not cause changes in DNA sequence. Changes in epigenetic modifications can be caused by exposure to certain environmental factors, such as contaminants like bisphenol A (BPA). Bisphenol A is ubiquitous in the environment and produced in large quantities, and known to have hormone-like activity, whereby disrupting endocrine function. Because of evidence for disruption of sex steroid mediated pathways, there is a concern that BPA could have adverse effects on female reproduction. The purpose of this review is to summarize the effects of BPA on adult female reproduction with focus on epigenetic changes that can be heritable.Entities:
Keywords: DNA methylation; Endocrine disruptors; Environmental toxins; Epigenetic; Female fertility; Histone modifications; Reproduction
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Year: 2016 PMID： 27591071 DOI： 10.1016/j.ygcen.2016.08.010
Source DB: PubMed Journal: Gen Comp Endocrinol ISSN： 0016-6480 Impact factor: 2.822