Literature DB >> 27591000

The Challenges Faced in Developing Novel Drug Radiation Combinations in Non-small Cell Lung Cancer.

S Harrow1, G G Hanna2, C Faivre-Finn3, F McDonald4, A J Chalmers5.   

Abstract

Lung cancer is the most common cancer diagnosed in the UK. Outcomes for patients with this disease remain poor and new strategies to treat this disease require investigation. One potential option is to combine novel agents with radiotherapy in clinical studies. Here we discuss some of the important issues to consider when combining novel agents with radiotherapy, together with potential solutions as discussed at a recent Clinical Translational Radiotherapy Group (CTRad) workshop. Crown
Copyright © 2016. Published by Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  DNA damage repair; NSCLC; immunotherapy; radiotherapy; umbrella study

Mesh:

Substances:

Year:  2016        PMID: 27591000     DOI: 10.1016/j.clon.2016.08.004

Source DB:  PubMed          Journal:  Clin Oncol (R Coll Radiol)        ISSN: 0936-6555            Impact factor:   4.126


  3 in total

Review 1.  Controversies in the role of radiotherapy in pleural mesothelioma.

Authors:  Gerard G Hanna; Thomas John; David L Ball
Journal:  Transl Lung Cancer Res       Date:  2021-04

2.  Phase I trial of the MEK inhibitor selumetinib in combination with thoracic radiotherapy in non-small cell lung cancer.

Authors:  K Haslett; P Koh; A Hudson; W D Ryder; S Falk; D Mullan; B Taylor; R Califano; F Blackhall; C Faivre-Finn
Journal:  Clin Transl Radiat Oncol       Date:  2021-02-25

3.  CONCORDE: A phase I platform study of novel agents in combination with conventional radiotherapy in non-small-cell lung cancer.

Authors:  Gerard M Walls; Jamie B Oughton; Anthony J Chalmers; Sarah Brown; Fiona Collinson; Martin D Forster; Kevin N Franks; Alexandra Gilbert; Gerard G Hanna; Nicola Hannaway; Stephen Harrow; Tom Haswell; Crispin T Hiley; Samantha Hinsley; Matthew Krebs; Geraldine Murden; Rachel Phillip; Anderson J Ryan; Ahmed Salem; David Sebag-Montefoire; Paul Shaw; Chris J Twelves; Katrina Walker; Robin J Young; Corinne Faivre-Finn; Alastair Greystoke
Journal:  Clin Transl Radiat Oncol       Date:  2020-09-22
  3 in total

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