Literature DB >> 27590780

Effect of lithium chloride on cell proliferation and osteogenic differentiation in stem cells from human exfoliated deciduous teeth.

Panarat Rattanawarawipa1, Prasit Pavasant2, Thanaphum Osathanon2, Waleerat Sukarawan3.   

Abstract

Lithium Chloride (LiCl) has been used as a canonical Wnt pathway activator due to its ability to inhibit a glycogen synthase kinase-3. The aim of the present study was to investigate the effect of LiCl on cell proliferation and osteogenic differentiation in stem cells isolated from human exfoliated deciduous teeth (SHEDs). SHEDs were isolated and cultured in media supplemented with LiCl at 5, 10, or 20mM. The results demonstrated that LiCl significantly decreased SHEDs colony forming unit ability in a dose dependent manner. LiCl significantly enhanced the percentage of cells in the sub G0 phase, accompanied by a reduction of the percentage of cells in the G1 phase at day 3 and 7 after treatment. Further, LiCl markedly decreased OSX and DMP1 mRNA expression after treating SHEDs in an osteogenic induction medium for 7 days. In addition, no significant difference in alkaline phosphatase enzymatic activity or mineral deposition was found. Together, these results imply that LiCl influences SHEDs behavior.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Differentiation; Lithium chloride; Osteogenic; Proliferation; Stem cells

Mesh：

Substances：

Year:  2016        PMID： 27590780     DOI： 10.1016/j.tice.2016.08.005

Source DB:  PubMed          Journal:  Tissue Cell        ISSN： 0040-8166            Impact factor:   2.466


  7 in total

1.  Lithium Chloride Promotes Milk Protein and Fat Synthesis in Bovine Mammary Epithelial Cells via HIF-1α and β-Catenin Signaling Pathways.

Authors:  Jinxin Zong; Jinglin Shen; Xinlu Liu; Jiayi Liu; Jing Zhang; Changhai Zhou; Yating Fan; Yongcheng Jin
Journal:  Biol Trace Elem Res       Date:  2022-01-26       Impact factor: 3.738

2.  Enhancing osteoblast differentiation through small molecule-incorporated engineered nanofibrous scaffold.

Authors:  Maria Akhtar; Kyung Mi Woo; Muhammad Tahir; Wenhui Wu; Jeevithan Elango; Munazza R Mirza; Maryam Khan; Saba Shamim; Praveen R Arany; Saeed Ur Rahman
Journal:  Clin Oral Investig       Date:  2021-10-22       Impact factor: 3.573

Review 3.  Multi-lineage differentiation and clinical application of stem cells from exfoliated deciduous teeth.

Authors:  Fei Xie; Jie He; Yingyi Chen; Ziqi Hu; Man Qin; Tianqian Hui
Journal:  Hum Cell       Date:  2020-01-31       Impact factor: 4.374

4.  Self-Assembling Peptide Scaffold Carrying Neural-Cell Adhesion Molecule-Derived Mimetic-Peptide Transplantation Promotes Proliferation and Stimulates Neurite Extension by Modulating Tau Phosphorylation and Calpain/Glycogen Synthase Kinase 3 beta (GSK-3β) in Neurons.

Authors:  Jian Xu; Jing Feng; Yu-Dong Liu; Tao Hu; Ming-Jing Li; Fan Li
Journal:  Ann Transplant       Date:  2020-07-07       Impact factor: 1.530

5.  DLX3 Inhibits the Proliferation of Human Dental Pulp Cells Through Inactivation of Canonical Wnt/β-Catenin Signaling Pathway.

Authors:  Yunyan Zhan; Xiaoyan Li; Xiaohui Gou; Guohua Yuan; Mingwen Fan; Guobin Yang
Journal:  Front Physiol       Date:  2018-11-20       Impact factor: 4.566

6.  6-Bromoindirubin-3'-Oxime Regulates Colony Formation, Apoptosis, and Odonto/Osteogenic Differentiation in Human Dental Pulp Stem Cells.

Authors:  Chatvadee Kornsuthisopon; Sunisa Rochanavibhata; Nunthawan Nowwarote; Kevin A Tompkins; Waleerat Sukarawan; Thanaphum Osathanon
Journal:  Int J Mol Sci       Date:  2022-08-04       Impact factor: 6.208

Review 7.  Osteogenic differentiation of periodontal membrane stem cells in inflammatory environments.

Authors:  Shenghao Jin; Haitao Jiang; Yue Sun; Fang Li; Jianglan Xia; Yaxin Li; Jiwei Zheng; Ying Qin
Journal:  Open Life Sci       Date:  2022-09-19       Impact factor: 1.311
  7 in total

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