Literature DB >> 27590768

Analysis of Immune Epitopes of Respiratory Syncytial Virus for Designing of Vectored Vaccines Based on Influenza Virus Platform.

I N Isakova-Sivak1, D A Korenkov2, E A Fedorova2, T S Tretiak2, V A Matyushenko2, T A Smolonogina2, L G Rudenko2.   

Abstract

The immunoepitope database was used for analysis of experimentally detected epitopes of the respiratory syncytial virus (RSV) proteins and for selection of the epitope combinations for subsequent designing of recombinant vectored anti-RSV vaccines based on attenuated influenza viruses. Three cassettes containing the most promising B- and T-cell RSV epitopes were selected: peptide F (243-294) supporting the formation of humoral immunity in animals; fragment M2-1 (70-101+114-146) containing two MHC I epitopes (82-90 and 127-135); and MHC II-epitope (51-66). The selected constructions contained no neoepitopes causing undesirable effects of vaccination, such as immunotolerance or autoimmunity.

Entities:  

Keywords:  immunodominant epitope; influenza virus; respiratory syncytial virus; vectored vaccine

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Year:  2016        PMID： 27590768     DOI： 10.1007/s10517-016-3454-7

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  2 in total

1.  Recombinant live attenuated influenza vaccine viruses carrying CD8 T-cell epitopes of respiratory syncytial virus protect mice against both pathogens without inflammatory disease.

Authors:  Tatiana Kotomina; Irina Isakova-Sivak; Victoria Matyushenko; Ki-Hye Kim; Youri Lee; Yu-Jin Jung; Sang-Moo Kang; Larisa Rudenko
Journal:  Antiviral Res       Date:  2019-05-07       Impact factor: 5.970

2.  Conserved T-cell epitopes of respiratory syncytial virus (RSV) delivered by recombinant live attenuated influenza vaccine viruses efficiently induce RSV-specific lung-localized memory T cells and augment influenza-specific resident memory T-cell responses.

Authors:  Victoria Matyushenko; Tatiana Kotomina; Igor Kudryavtsev; Daria Mezhenskaya; Polina Prokopenko; Anastasia Matushkina; Konstantin Sivak; Arman Muzhikyan; Larisa Rudenko; Irina Isakova-Sivak
Journal:  Antiviral Res       Date:  2020-06-22       Impact factor: 5.970
  2 in total

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