Literature DB >> 27590734

Genome microsatellite diversity within the Apicomplexa phylum.

Juan Pablo Isaza1,2, Juan Fernando Alzate3,4.   

Abstract

The Apicomplexa phylum groups include unicellular and obligate intracellular protozoan parasites with an apical complex used for attachment and invasion to host cells. In this study, we analyze single sequence repeats (SSRs) in the whole genome of 20 apicomplexan organisms that represent four different lineages within the phylum. Only perfect SSRs with at least 12 nucleotides and composed of 2-6 mers were included. To better understand the association of SSR types with the genomic regions, the SSRs were classified accordingly with the genomic location into exon, intron and intergenic categories. Our results showed heterogeneous SSRs density within the studied genomes. However, the most frequent SSRs types were di- and tri-nucleotide repeats. The former was associated with intergenic regions, while the latter was associated with exon regions.

Entities:  

Keywords:  Apicomplexa; Comparative genomics; Microsatellites; Parasite genomics; Single sequence repeats

Mesh:

Year:  2016        PMID: 27590734     DOI: 10.1007/s00438-016-1244-6

Source DB:  PubMed          Journal:  Mol Genet Genomics        ISSN: 1617-4623            Impact factor:   3.291


  66 in total

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Journal:  Science       Date:  2005-07-01       Impact factor: 47.728

4.  The comparative genomics of polyglutamine repeats: extreme differences in the codon organization of repeat-encoding regions between mammals and Drosophila.

Authors:  M M Albà; M F Santibáñez-Koref; J M Hancock
Journal:  J Mol Evol       Date:  2001-03       Impact factor: 2.395

5.  Predicting the Genetic Stability of Engineered DNA Sequences with the EFM Calculator.

Authors:  Benjamin R Jack; Sean P Leonard; Dennis M Mishler; Brian A Renda; Dacia Leon; Gabriel A Suárez; Jeffrey E Barrick
Journal:  ACS Synth Biol       Date:  2015-07-01       Impact factor: 5.110

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8.  Cryptic simplicity in DNA is a major source of genetic variation.

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Authors:  Lowell S Kappmeyer; Mathangi Thiagarajan; David R Herndon; Joshua D Ramsay; Elisabet Caler; Appolinaire Djikeng; Joseph J Gillespie; Audrey Ot Lau; Eric H Roalson; Joana C Silva; Marta G Silva; Carlos E Suarez; Massaro W Ueti; Vishvanath M Nene; Robert H Mealey; Donald P Knowles; Kelly A Brayton
Journal:  BMC Genomics       Date:  2012-11-09       Impact factor: 3.969

10.  Inconsistencies of genome annotations in apicomplexan parasites revealed by 5'-end-one-pass and full-length sequences of oligo-capped cDNAs.

Authors:  Hiroyuki Wakaguri; Yutaka Suzuki; Masahide Sasaki; Sumio Sugano; Junichi Watanabe
Journal:  BMC Genomics       Date:  2009-07-15       Impact factor: 3.969

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