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Literature DB >> 27590574

Design, synthesis and evaluation of 3-quinoline carboxylic acids as new inhibitors of protein kinase CK2.

Anatolii R Syniugin¹, Olga V Ostrynska¹, Maksym O Chekanov¹, Galyna P Volynets¹, Sergiy A Starosyla¹, Volodymyr G Bdzhola¹, Sergiy M Yarmoluk¹.

Abstract

In this article, the derivatives of 3-quinoline carboxylic acid were studied as inhibitors of protein kinase CK2. Forty-three new compounds were synthesized. Among them 22 compounds inhibiting CK2 with IC50 in the range from 0.65 to 18.2 μM were identified. The most active inhibitors were found among tetrazolo-quinoline-4-carboxylic acid and 2-aminoquinoline-3-carboxylic acid derivatives.

Entities: Chemical

Keywords: 2-aminoquinoline-3-carboxylic acid; 2-chloroquinoline-3-carboxylic acid; 2-oxo-1,2-dihydroquinoline-3-carboxylic acid; 5-oxo-2,3-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-6-carboxylic acid; Inhibitor; protein kinase CK2; tetrazolo[1,5-a]quinoline-4-carboxylic acid

Mesh：

Substances：

Year: 2016 PMID： 27590574 DOI： 10.1080/14756366.2016.1222584

Source DB: PubMed Journal: J Enzyme Inhib Med Chem ISSN： 1475-6366 Impact factor: 5.051

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Cited

4 in total

4. Synthesis, X-ray diffraction study, analysis of inter-molecular inter-actions and mol-ecular docking of ethyl 1-(3-tosyl-quinolin-4-yl)piperidine-4-carboxyl-ate.

Authors: Yevhenii Vaksler; Halyna V Hryhoriv; Sergiy M Kovalenko; Lina O Perekhoda; Victoriya A Georgiyants
Journal: Acta Crystallogr E Crystallogr Commun Date: 2022-08-09

4 in total

Design, synthesis and evaluation of 3-quinoline carboxylic acids as new inhibitors of protein kinase CK2.

1. Impact of in Situ Simulated Climate Change on Communities and Non-Indigenous Species: Two Climates, Two Responses.

2. Inhibitory influence of natural flavonoids on human protein kinase CK2 isoforms: effect of the regulatory subunit.

3. A simple and efficient copper-catalyzed three-component reaction to synthesize (Z)-1,2-dihydro-2-iminoquinolines.

4. Synthesis, X-ray diffraction study, analysis of inter-molecular inter-actions and mol-ecular docking of ethyl 1-(3-tosyl-quinolin-4-yl)piperidine-4-carboxyl-ate.