R Carney1, A R Yung2, G P Amminger3, T Bradshaw4, N Glozier5, D F Hermens5, I B Hickie5, E Killackey6, P McGorry6, C Pantelis7, S J Wood8, R Purcell6. 1. Institute of Brain, Behaviour and Mental Health, University of Manchester, UK. Electronic address: rebekah.carney@postgrad.manchester.ac.uk. 2. Institute of Brain, Behaviour and Mental Health, University of Manchester, UK; Greater Manchester West Mental Health NHS Foundation Trust, UK. 3. Orygen - The National Centre of Excellence in Youth Mental Health, University of Melbourne, Victoria, Australia; The Centre for Youth Mental Health, The University of Melbourne, Australia. 4. School of Nursing, Midwifery and Social Work, University of Manchester, UK. 5. Brain & Mind Centre, University of Sydney, New South Wales, Australia. 6. Orygen - The National Centre of Excellence in Youth Mental Health, University of Melbourne, Victoria, Australia. 7. Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Victoria, Australia. 8. Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Victoria, Australia; School of Psychology, University of Birmingham, UK.
Abstract
BACKGROUND: People with schizophrenia have high rates of substance use which contributes to co-morbidity and premature mortality. Some evidence suggests people at-risk for psychosis have high rates of substance use. We aimed to assess substance use in a help-seeking cohort, comparing those at-risk and not at-risk for psychosis, and to establish any relationship with clinical symptoms. METHOD: Participants were help-seeking youth presenting to mental health services in Sydney and Melbourne. 279 (34.8%) were at-risk for psychosis, and 452 (56.4%) did not meet criteria for a psychotic disorder or risk for psychosis. The excluded individuals were made up of 59 (7.4%) young people who met criteria for a psychotic disorder and 11 (1.4%) who were unable to be evaluated. We assessed the association of substance use involvement with risk status and clinical symptoms using multivariate regression. RESULTS: Individuals at-risk for psychosis had significantly higher tobacco, alcohol and cannabis use than those not at-risk. Multivariate analysis revealed at-risk status was significantly associated with higher alcohol involvement scores when adjusting for age and gender, but no association was found for cannabis or tobacco. At-risk status was no longer associated with alcohol involvement when cannabis or tobacco use was added into the analysis. CONCLUSION: Tobacco smoking, alcohol consumption and cannabis use are common in help-seeking youth, particularly those at-risk for psychosis. It is important to consider co-occurring use of different substances in adolescents. Early substance misuse in this phase of illness could be targeted to improve physical and mental health in young people.
BACKGROUND:People with schizophrenia have high rates of substance use which contributes to co-morbidity and premature mortality. Some evidence suggests people at-risk for psychosis have high rates of substance use. We aimed to assess substance use in a help-seeking cohort, comparing those at-risk and not at-risk for psychosis, and to establish any relationship with clinical symptoms. METHOD:Participants were help-seeking youth presenting to mental health services in Sydney and Melbourne. 279 (34.8%) were at-risk for psychosis, and 452 (56.4%) did not meet criteria for a psychotic disorder or risk for psychosis. The excluded individuals were made up of 59 (7.4%) young people who met criteria for a psychotic disorder and 11 (1.4%) who were unable to be evaluated. We assessed the association of substance use involvement with risk status and clinical symptoms using multivariate regression. RESULTS: Individuals at-risk for psychosis had significantly higher tobacco, alcohol and cannabis use than those not at-risk. Multivariate analysis revealed at-risk status was significantly associated with higher alcohol involvement scores when adjusting for age and gender, but no association was found for cannabis or tobacco. At-risk status was no longer associated with alcohol involvement when cannabis or tobacco use was added into the analysis. CONCLUSION:Tobacco smoking, alcohol consumption and cannabis use are common in help-seeking youth, particularly those at-risk for psychosis. It is important to consider co-occurring use of different substances in adolescents. Early substance misuse in this phase of illness could be targeted to improve physical and mental health in young people.
Authors: K Filia; D Rickwood; J Menssink; C X Gao; S Hetrick; A Parker; M Hamilton; I Hickie; H Herrman; N Telford; S Sharmin; P McGorry; S Cotton Journal: Soc Psychiatry Psychiatr Epidemiol Date: 2021-01-16 Impact factor: 4.328
Authors: Malvina O Pietrzykowski; Katrina M Daigle; Abigail B Waters; Lance P Swenson; David A Gansler Journal: Brain Imaging Behav Date: 2021-11-13 Impact factor: 3.978
Authors: Patrick Köck; Maximilian Meyer; Julie Elsner; Kenneth M Dürsteler; Marc Vogel; Marc Walter Journal: Front Psychiatry Date: 2022-02-24 Impact factor: 4.157
Authors: David M Weiss; Elizabeth Bernier; Douglas R Robbins; Katherine M Elacqua; Kelsey A Johnson; Kate Powers; Raquelle I Mesholam-Gately; Kristen A Woodberry Journal: Front Psychiatry Date: 2022-05-03 Impact factor: 4.157