Literature DB >> 27590080

Metabolic monitoring and management among clozapine users.

Grace Tso1, Puja Kumar1, Thilini Jayasooriya2, Steve Kisely3, Dan Siskind4.   

Abstract

OBJECTIVE: To assess, among clozapine users, the rates of monitoring, presence and treatment of metabolic syndrome and its components.
METHODS: A chart review was conducted of all clozapine users who were followed up in community mental health clinics at two Metro South Health Hospitals over a 1-year period. Metabolic syndrome was diagnosed according to the International Diabetes Federation criteria.
RESULTS: We included 251 clozapine users. Only 43.4% (109/251) had data collected for all five metabolic syndrome parameters. Among these people, 45.0% (49/109) met criteria for metabolic syndrome, while 61.2% (30/49) of those with metabolic syndrome were offered appropriate treatments. Correspondence with primary care providers occurred in only 18.7% ( n = 47). Non-pharmacological interventions, such as motivational interviewing and education about healthy lifestyle alternatives, occurred in 49.8% ( n = 125).
CONCLUSIONS: There is growing awareness of the importance of metabolic monitoring, however, there remain specific gaps in the collaborative work among mental health services, primary care providers and clozapine users, to ensure appropriate physical health interventions.

Entities:  

Keywords:  antipsychotic; clozapine; metabolic monitoring; metabolic syndrome; psychosis

Mesh:

Substances:

Year:  2016        PMID: 27590080     DOI: 10.1177/1039856216665282

Source DB:  PubMed          Journal:  Australas Psychiatry        ISSN: 1039-8562            Impact factor:   1.369


  7 in total

Review 1.  Safety of antipsychotics for the treatment of schizophrenia: a focus on the adverse effects of clozapine.

Authors:  Domenico De Berardis; Gabriella Rapini; Luigi Olivieri; Domenico Di Nicola; Carmine Tomasetti; Alessandro Valchera; Michele Fornaro; Fabio Di Fabio; Giampaolo Perna; Marco Di Nicola; Gianluca Serafini; Alessandro Carano; Maurizio Pompili; Federica Vellante; Laura Orsolini; Giovanni Martinotti; Massimo Di Giannantonio
Journal:  Ther Adv Drug Saf       Date:  2018-02-06

2.  Frailty and Treatment-Resistant Schizophrenia: A Retrospective Cohort Study.

Authors:  Ella Pearson; Dan Siskind; Ruth Hubbard; Emily Gordon; Elizabeth Coulson; Urska Arnautovska; Nicola Warren
Journal:  Community Ment Health J       Date:  2022-07-05

3.  Pharmacists in clozapine clinics improving physical health monitoring.

Authors:  Greg Spann; Lewis Austin; Edward King
Journal:  Ment Health Clin       Date:  2022-06-10

4.  Metformin reduces 12-month change in body weight among people newly commenced on clozapine: a retrospective naturalistic cohort study.

Authors:  Jessica Spokes; Samantha Hollingworth; Karl Winckel; Steve Kisely; Andrea Baker; Peter Cosgrove; Dan Siskind
Journal:  Ther Adv Psychopharmacol       Date:  2021-03-16

Review 5.  A Focused Review of the Metabolic Side-Effects of Clozapine.

Authors:  Jessica W Y Yuen; David D Kim; Ric M Procyshyn; William J Panenka; William G Honer; Alasdair M Barr
Journal:  Front Endocrinol (Lausanne)       Date:  2021-02-25       Impact factor: 5.555

6.  Associations between plasma clozapine/N-desmethylclozapine ratio, insulin resistance and cognitive performance in patients with co-morbid obesity and ultra-treatment resistant schizophrenia.

Authors:  Kenya A Costa-Dookhan; Tarek K Rajji; Veronica N Tran; Sylvie Bowden; Daniel J Mueller; Gary J Remington; Sri Mahavir Agarwal; Margaret K Hahn
Journal:  Sci Rep       Date:  2021-01-21       Impact factor: 4.379

Review 7.  Systematic review and meta-analysis of the provision of preventive care for modifiable chronic disease risk behaviours by mental health services.

Authors:  Jacqueline M Bailey; Kate M Bartlem; John H Wiggers; Paula M Wye; Emily A L Stockings; Rebecca K Hodder; Alexandra P Metse; Tim W Regan; Richard Clancy; Julia A Dray; Danika L Tremain; Tegan Bradley; Jenny A Bowman
Journal:  Prev Med Rep       Date:  2019-08-14
  7 in total

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