Literature DB >> 27589079

Long-Term Follow-Up after Treatment of Cryptorchidism.

Jorgen Thorup1, Dina Cortes2.   

Abstract

When considering long-term prognosis and results in adult age following treatment of cryptorchidism in childhood there are three main issues to be discussed: cosmetics, fertility, and malignancy. In the present review, the most recent research on the topics related to summaries of well-known knowledge on the field is presented.To some extent a smaller testis in a higher scrotal position than normal must be accepted as a fair cosmetic result after orchidopexy in childhood. The smaller testis size is related to the impaired fertility potential of the testis. In cases with atrophy, testicular prosthesis implantation is an option with good operative results. The risk of impaired fertility potential in adults treated in childhood for cryptorchidism is still significant and worst in bilateral disease. We need repetitive solid long-term follow-up data to show that orchidopexy performed within first year of life has markedly improved the fertility potential. Men previously having orchidopexy for cryptorchidism related to intra-abdominal testes, abnormal external genitalia and/or abnormal karyotype, and/or hypospadias are of special increased risk of developing testicular cancer. In these cases intratubular germ cell neoplasia may be diagnosed in prepubertal age. Early orchidopexy may lower the risk of developing testicular cancer. Georg Thieme Verlag KG Stuttgart · New York.

Entities:  

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Year:  2016        PMID: 27589079     DOI: 10.1055/s-0036-1592138

Source DB:  PubMed          Journal:  Eur J Pediatr Surg        ISSN: 0939-7248            Impact factor:   2.191


  4 in total

1.  Characterization and Survival of Human Infant Testicular Cells After Direct Xenotransplantation.

Authors:  Danyang Wang; Simone Hildorf; Elissavet Ntemou; Lihua Dong; Susanne Elisabeth Pors; Linn Salto Mamsen; Jens Fedder; Eva R Hoffmann; Erik Clasen-Linde; Dina Cortes; Jørgen Thorup; Claus Yding Andersen
Journal:  Front Endocrinol (Lausanne)       Date:  2022-03-10       Impact factor: 5.555

2.  Synchronous Testicular Cancer in Monozygotic Twins.

Authors:  Ioannis Manolitsis; Lazaros Tzelves; Themistoklis Bellos; Marinos Berdempes; Andreas Skolarikos
Journal:  Cureus       Date:  2022-03-08

3.  Organotypic Culture of Testicular Tissue from Infant Boys with Cryptorchidism.

Authors:  Danyang Wang; Simone Hildorf; Elissavet Ntemou; Linn Salto Mamsen; Lihua Dong; Susanne Elisabeth Pors; Jens Fedder; Erik Clasen-Linde; Dina Cortes; Jørgen Thorup; Claus Yding Andersen
Journal:  Int J Mol Sci       Date:  2022-07-19       Impact factor: 6.208

4.  Xeno-Free Propagation of Spermatogonial Stem Cells from Infant Boys.

Authors:  Lihua Dong; Murat Gul; Simone Hildorf; Susanne Elisabeth Pors; Stine Gry Kristensen; Eva R Hoffmann; Dina Cortes; Jorgen Thorup; Claus Yding Andersen
Journal:  Int J Mol Sci       Date:  2019-10-29       Impact factor: 5.923

  4 in total

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